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First Total Synthesis and in Vitro Cytotoxicities of Flavesines G and J

[Image: see text] The first total synthesis of flavesines G and J, natural products exhibiting antiviral activity against hepatitis B virus, is described. A robust, protecting-group-free route starting from commercially available natural product 9-azajulolidine allowed us to obtain the title compoun...

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Detalles Bibliográficos
Autores principales: Pelss, Juris, Smits, Gints
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271405/
https://www.ncbi.nlm.nih.gov/pubmed/32548440
http://dx.doi.org/10.1021/acsomega.0c01672
Descripción
Sumario:[Image: see text] The first total synthesis of flavesines G and J, natural products exhibiting antiviral activity against hepatitis B virus, is described. A robust, protecting-group-free route starting from commercially available natural product 9-azajulolidine allowed us to obtain the title compounds in a four- and five-step sequence accordingly. Flavesines G and J exhibit micromolar cytotoxicity in A549, MCF-7, HepG2, PANC-1, and HL-60 cancer cell lines.