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First Total Synthesis and in Vitro Cytotoxicities of Flavesines G and J
[Image: see text] The first total synthesis of flavesines G and J, natural products exhibiting antiviral activity against hepatitis B virus, is described. A robust, protecting-group-free route starting from commercially available natural product 9-azajulolidine allowed us to obtain the title compoun...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271405/ https://www.ncbi.nlm.nih.gov/pubmed/32548440 http://dx.doi.org/10.1021/acsomega.0c01672 |
| _version_ | 1783542084367548416 |
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| author | Pelss, Juris Smits, Gints |
| author_facet | Pelss, Juris Smits, Gints |
| author_sort | Pelss, Juris |
| collection | PubMed |
| description | [Image: see text] The first total synthesis of flavesines G and J, natural products exhibiting antiviral activity against hepatitis B virus, is described. A robust, protecting-group-free route starting from commercially available natural product 9-azajulolidine allowed us to obtain the title compounds in a four- and five-step sequence accordingly. Flavesines G and J exhibit micromolar cytotoxicity in A549, MCF-7, HepG2, PANC-1, and HL-60 cancer cell lines. |
| format | Online Article Text |
| id | pubmed-7271405 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2020 |
| publisher | American Chemical Society |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-72714052020-06-15 First Total Synthesis and in Vitro Cytotoxicities of Flavesines G and J Pelss, Juris Smits, Gints ACS Omega [Image: see text] The first total synthesis of flavesines G and J, natural products exhibiting antiviral activity against hepatitis B virus, is described. A robust, protecting-group-free route starting from commercially available natural product 9-azajulolidine allowed us to obtain the title compounds in a four- and five-step sequence accordingly. Flavesines G and J exhibit micromolar cytotoxicity in A549, MCF-7, HepG2, PANC-1, and HL-60 cancer cell lines. American Chemical Society 2020-05-19 /pmc/articles/PMC7271405/ /pubmed/32548440 http://dx.doi.org/10.1021/acsomega.0c01672 Text en Copyright © 2020 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes. |
| spellingShingle | Pelss, Juris Smits, Gints First Total Synthesis and in Vitro Cytotoxicities of Flavesines G and J |
| title | First Total Synthesis and in Vitro Cytotoxicities of Flavesines G and J |
| title_full | First Total Synthesis and in Vitro Cytotoxicities of Flavesines G and J |
| title_fullStr | First Total Synthesis and in Vitro Cytotoxicities of Flavesines G and J |
| title_full_unstemmed | First Total Synthesis and in Vitro Cytotoxicities of Flavesines G and J |
| title_short | First Total Synthesis and in Vitro Cytotoxicities of Flavesines G and J |
| title_sort | first total synthesis and in vitro cytotoxicities of flavesines g and j |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271405/ https://www.ncbi.nlm.nih.gov/pubmed/32548440 http://dx.doi.org/10.1021/acsomega.0c01672 |
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