18β-Glycyrrhetinic acid induces human HaCaT keratinocytes apoptosis through ROS-mediated PI3K-Akt signaling pathway and ameliorates IMQ-induced psoriasis-like skin lesions in mice

BACKGROUND: Psoriasis is a chronic inflammatory skin disease affecting 2–3% of the population worldwide. Hyperproliferative keratinocytes were thought to be an amplifier of inflammatory response, thereby sustaining persistence of psoriasis lesions. Agents with the ability to inhibit keratinocyte pro...

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Detalles Bibliográficos
Autores principales: Gao, Jintao, Guo, Junfan, Nong, Yuejuan, Mo, Wenfei, Fang, Huanan, Mi, Jing, Qi, Qi, Yang, Mengjuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271483/
https://www.ncbi.nlm.nih.gov/pubmed/32493482
http://dx.doi.org/10.1186/s40360-020-00419-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271483/
https://www.ncbi.nlm.nih.gov/pubmed/32493482
http://dx.doi.org/10.1186/s40360-020-00419-0

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