Human laminin-111 and laminin-211 protein therapy prevents muscle disease progression in an immunodeficient mouse model of LAMA2-CMD

BACKGROUND: Laminin-α2-related congenital muscular dystrophy (LAMA2-CMD) is a devastating genetic disease caused by mutations in the LAMA2 gene. These mutations result in progressive muscle wasting and inflammation leading to delayed milestones, and reduced lifespan in affected patients. There is cu...

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Detalles Bibliográficos
Autores principales: Barraza-Flores, Pamela, Hermann, Hailey J., Bates, Christina R., Allen, Tyler G., Grunert, Timothy T., Burkin, Dean J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271547/
https://www.ncbi.nlm.nih.gov/pubmed/32498713
http://dx.doi.org/10.1186/s13395-020-00235-4

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