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Adverse reaction to Ficus Carica: reported case of a possible cross-reactivity with Der p1

BACKGROUND: Ficus carica is an edible fruit, belonging to the Moraceae family, rarely described as cause of food allergy. We describe the first case of fig allergy that occurred as a cross-reactivity between fig and Derp 1. CASE PRESENTATION: We present a case of a 10-years-old-girl, with a history...

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Autores principales: Urbani, S., Aruanno, A., Nucera, E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271553/
https://www.ncbi.nlm.nih.gov/pubmed/32518529
http://dx.doi.org/10.1186/s12948-020-00125-6
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author Urbani, S.
Aruanno, A.
Nucera, E.
author_facet Urbani, S.
Aruanno, A.
Nucera, E.
author_sort Urbani, S.
collection PubMed
description BACKGROUND: Ficus carica is an edible fruit, belonging to the Moraceae family, rarely described as cause of food allergy. We describe the first case of fig allergy that occurred as a cross-reactivity between fig and Derp 1. CASE PRESENTATION: We present a case of a 10-years-old-girl, with a history of no-seasonal mild intermittent rhinitis, who experienced an immediate reaction after ingestion of a fresh fig. Skin prick tests (SPT) with commercial extracts of food, airborne allergens, latex and panallergens (profilin, PR-10 and lipid transfer protein) were performed. SPT revealed a sensitization only for dermatophagoides farina and dermatophagoides pteronyssinus which was then confirmed with by specific IgE assay (UniCAP, Phadia, Uppsala, Sweden). We also carried out a positive SPT with a commercial fig allergen (Lofarma, Milan, Italy) and prick-by-prick (PBP) both with skin and pulp of green raw and cooked fig. Fig specific serum IgE levels were 1.08 U/ml and specific IgE for rDer p1 was 16.20 U/ml (total serum IgE = 377 U/ml). In contrast specific IgE levels for latex, LTP, profilin, PR-10 and pollen allergens were negative. CONCLUSION: The ficin, the major fig allergen, belongs to cysteine protease family like Der p 1. The symptoms presented by our patient could be related to a cross reactivity between these two proteins which present a structural homology.
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spelling pubmed-72715532020-06-08 Adverse reaction to Ficus Carica: reported case of a possible cross-reactivity with Der p1 Urbani, S. Aruanno, A. Nucera, E. Clin Mol Allergy Case Report BACKGROUND: Ficus carica is an edible fruit, belonging to the Moraceae family, rarely described as cause of food allergy. We describe the first case of fig allergy that occurred as a cross-reactivity between fig and Derp 1. CASE PRESENTATION: We present a case of a 10-years-old-girl, with a history of no-seasonal mild intermittent rhinitis, who experienced an immediate reaction after ingestion of a fresh fig. Skin prick tests (SPT) with commercial extracts of food, airborne allergens, latex and panallergens (profilin, PR-10 and lipid transfer protein) were performed. SPT revealed a sensitization only for dermatophagoides farina and dermatophagoides pteronyssinus which was then confirmed with by specific IgE assay (UniCAP, Phadia, Uppsala, Sweden). We also carried out a positive SPT with a commercial fig allergen (Lofarma, Milan, Italy) and prick-by-prick (PBP) both with skin and pulp of green raw and cooked fig. Fig specific serum IgE levels were 1.08 U/ml and specific IgE for rDer p1 was 16.20 U/ml (total serum IgE = 377 U/ml). In contrast specific IgE levels for latex, LTP, profilin, PR-10 and pollen allergens were negative. CONCLUSION: The ficin, the major fig allergen, belongs to cysteine protease family like Der p 1. The symptoms presented by our patient could be related to a cross reactivity between these two proteins which present a structural homology. BioMed Central 2020-06-03 /pmc/articles/PMC7271553/ /pubmed/32518529 http://dx.doi.org/10.1186/s12948-020-00125-6 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Case Report
Urbani, S.
Aruanno, A.
Nucera, E.
Adverse reaction to Ficus Carica: reported case of a possible cross-reactivity with Der p1
title Adverse reaction to Ficus Carica: reported case of a possible cross-reactivity with Der p1
title_full Adverse reaction to Ficus Carica: reported case of a possible cross-reactivity with Der p1
title_fullStr Adverse reaction to Ficus Carica: reported case of a possible cross-reactivity with Der p1
title_full_unstemmed Adverse reaction to Ficus Carica: reported case of a possible cross-reactivity with Der p1
title_short Adverse reaction to Ficus Carica: reported case of a possible cross-reactivity with Der p1
title_sort adverse reaction to ficus carica: reported case of a possible cross-reactivity with der p1
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271553/
https://www.ncbi.nlm.nih.gov/pubmed/32518529
http://dx.doi.org/10.1186/s12948-020-00125-6
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