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D’ domain region Arg782-Cys799 of von Willebrand factor contributes to factor VIII binding
In the complex with von Willebrand factor (VWF) factor VIII (FVIII) is protected from rapid clearance from circulation. Although it has been established that the FVIII binding site resides in the N-terminal D’-D3 domains of VWF, detailed information about the amino acid regions that contribute to FV...
Autores principales: | Przeradzka, Małgorzata A., van Galen, Josse, Ebberink, Eduard H. T. M., Hoogendijk, Arie J., van der Zwaan, Carmen, Mertens, Koen, van den Biggelaar, Maartje, Meijer, Alexander B. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ferrata Storti Foundation
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271574/ https://www.ncbi.nlm.nih.gov/pubmed/31558672 http://dx.doi.org/10.3324/haematol.2019.221994 |
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