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Ile73Asn mutation in protein C introduces a new N-linked glycosylation site on the first EGF-domain of protein C and causes thrombosis

Activated protein C exerts its anticoagulant activity by protein S-dependent inactivation of factors Va and VIIIa by limited proteolysis. We identified a venous thrombosis patient who has plasma protein C antigen level of 63% and activity levels of 44% and 23%, as monitored by chromogenic and clotti...

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Detalles Bibliográficos
Autores principales:	Lu, Yeling, Mehta-D’souza, Padmaja, Biswas, Indranil, Villoutreix, Bruno O., Wang, Xuefeng, Ding, Qiulan, Rezaie, Alireza R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ferrata Storti Foundation 2020
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271577/ https://www.ncbi.nlm.nih.gov/pubmed/31399531 http://dx.doi.org/10.3324/haematol.2019.227033

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