LIM-only protein FHL2 attenuates vascular tissue factor activity, inhibits thrombus formation in mice and FHL2 genetic variation associates with human venous thrombosis

Bleeding disorders and thrombotic complications are major causes of morbidity and mortality with many cases being unexplained. Thrombus formation involves aberrant expression and activation of tissue factor (TF) in vascular endothelial and smooth muscle cells. Here, we sought to identify factors tha...

Descripción completa

Detalles Bibliográficos
Autores principales: Kroone, Chantal, Vos, Mariska, Rademakers, Timo, Kuijpers, Marijke, Hoogenboezem, Mark, van Buul, Jaap, Heemskerk, Johan W.M., Ruf, Wolfram, van Hylckama Vlieg, Astrid, Versteeg, Henri H., Goumans, Marie-José, de Vries, Carlie J.M., Kurakula, Kondababu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ferrata Storti Foundation 2020
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271603/
https://www.ncbi.nlm.nih.gov/pubmed/31467128
http://dx.doi.org/10.3324/haematol.2018.203026

Ejemplares similares

Ejemplares similares