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Dynamics of digital ulcers in systemic sclerosis

Systemic sclerosis (SSc) is a collagenosis with insufficiently known etiopathogenesis, characterized by microvasculopathy and excessive fibrosis in the context of an autoimmune disorder. The incompletely elucidated pathogenesis and limited therapeutic options, disabling aspects, skin lesions and pai...

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Autores principales: Bobeică, Carmen, Tatu, Alin Laurențiu, Crăescu, Mihaela, Solovăstru, Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271728/
https://www.ncbi.nlm.nih.gov/pubmed/32508995
http://dx.doi.org/10.3892/etm.2020.8572
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author Bobeică, Carmen
Tatu, Alin Laurențiu
Crăescu, Mihaela
Solovăstru, Laura
author_facet Bobeică, Carmen
Tatu, Alin Laurențiu
Crăescu, Mihaela
Solovăstru, Laura
author_sort Bobeică, Carmen
collection PubMed
description Systemic sclerosis (SSc) is a collagenosis with insufficiently known etiopathogenesis, characterized by microvasculopathy and excessive fibrosis in the context of an autoimmune disorder. The incompletely elucidated pathogenesis and limited therapeutic options, disabling aspects, skin lesions and pain determine important functional and psychological deficiencies which affect the quality of life. It is imperative to observe and correlate individual clinical and paraclinical data to optimize disease management. A group of 22 patients diagnosed with SSc, hospitalized in a university clinic in Bucharest was included in an observational study. The evolution of digital ulcers was evaluated as an indicator of vasculopathy and their status and dynamics were correlated with clinical elements reflecting the fibrotic aspect of the disease. The present study shows that the Raynaud phenomenon is almost always present during the course of the disease, but its presence is not always associated with digital ulcers. The existing data in the literature show that fibrosis is subsequent to vasculopathy, but this study did not reveal causality between these two aspects of pathogenesis. The presence of microstomia and digital contracture was identified in the presence of digital ulcers, but also in their absence. The etiopathogenic mechanisms with multiple unknown involved factors open the opportunity to investigate many aspects of SSc for optimal aiming of therapeutic interventions.
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spelling pubmed-72717282020-06-05 Dynamics of digital ulcers in systemic sclerosis Bobeică, Carmen Tatu, Alin Laurențiu Crăescu, Mihaela Solovăstru, Laura Exp Ther Med Articles Systemic sclerosis (SSc) is a collagenosis with insufficiently known etiopathogenesis, characterized by microvasculopathy and excessive fibrosis in the context of an autoimmune disorder. The incompletely elucidated pathogenesis and limited therapeutic options, disabling aspects, skin lesions and pain determine important functional and psychological deficiencies which affect the quality of life. It is imperative to observe and correlate individual clinical and paraclinical data to optimize disease management. A group of 22 patients diagnosed with SSc, hospitalized in a university clinic in Bucharest was included in an observational study. The evolution of digital ulcers was evaluated as an indicator of vasculopathy and their status and dynamics were correlated with clinical elements reflecting the fibrotic aspect of the disease. The present study shows that the Raynaud phenomenon is almost always present during the course of the disease, but its presence is not always associated with digital ulcers. The existing data in the literature show that fibrosis is subsequent to vasculopathy, but this study did not reveal causality between these two aspects of pathogenesis. The presence of microstomia and digital contracture was identified in the presence of digital ulcers, but also in their absence. The etiopathogenic mechanisms with multiple unknown involved factors open the opportunity to investigate many aspects of SSc for optimal aiming of therapeutic interventions. D.A. Spandidos 2020-07 2020-02-27 /pmc/articles/PMC7271728/ /pubmed/32508995 http://dx.doi.org/10.3892/etm.2020.8572 Text en Copyright: © Bobeică et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Bobeică, Carmen
Tatu, Alin Laurențiu
Crăescu, Mihaela
Solovăstru, Laura
Dynamics of digital ulcers in systemic sclerosis
title Dynamics of digital ulcers in systemic sclerosis
title_full Dynamics of digital ulcers in systemic sclerosis
title_fullStr Dynamics of digital ulcers in systemic sclerosis
title_full_unstemmed Dynamics of digital ulcers in systemic sclerosis
title_short Dynamics of digital ulcers in systemic sclerosis
title_sort dynamics of digital ulcers in systemic sclerosis
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271728/
https://www.ncbi.nlm.nih.gov/pubmed/32508995
http://dx.doi.org/10.3892/etm.2020.8572
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