Patients with COVID-19 and neurological manifestations show undetectable SARS-CoV-2 RNA levels in the cerebrospinal fluid

We report that patients with COVID-19 displaying distinct neurological disorders have undetectable or extremely low levels of SARS-CoV-2 RNA in the cerebrospinal fluid, indicating that viral clearance precede the neurological involvement. This finding points to the need for the development of more s...

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Detalles Bibliográficos
Autores principales: Espíndola, Otávio de Melo, Siqueira, Marilda, Soares, Cristiane Nascimento, Lima, Marco Antonio Sales Dantas de, Leite, Ana Claudia Celestino Bezerra, Araujo, Abelardo Queiroz Campos, Brandão, Carlos Otávio, Silva, Marcus Tulius Teixeira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271861/
https://www.ncbi.nlm.nih.gov/pubmed/32505878
http://dx.doi.org/10.1016/j.ijid.2020.05.123
Descripción
Sumario:We report that patients with COVID-19 displaying distinct neurological disorders have undetectable or extremely low levels of SARS-CoV-2 RNA in the cerebrospinal fluid, indicating that viral clearance precede the neurological involvement. This finding points to the need for the development of more sensitive molecular tests and the investigation of other neurotropic pathogens to exclude concurrent neuroinfection.

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