Patients with COVID-19 and neurological manifestations show undetectable SARS-CoV-2 RNA levels in the cerebrospinal fluid

We report that patients with COVID-19 displaying distinct neurological disorders have undetectable or extremely low levels of SARS-CoV-2 RNA in the cerebrospinal fluid, indicating that viral clearance precede the neurological involvement. This finding points to the need for the development of more s...

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Autores principales: Espíndola, Otávio de Melo, Siqueira, Marilda, Soares, Cristiane Nascimento, Lima, Marco Antonio Sales Dantas de, Leite, Ana Claudia Celestino Bezerra, Araujo, Abelardo Queiroz Campos, Brandão, Carlos Otávio, Silva, Marcus Tulius Teixeira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271861/
https://www.ncbi.nlm.nih.gov/pubmed/32505878
http://dx.doi.org/10.1016/j.ijid.2020.05.123
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author Espíndola, Otávio de Melo
Siqueira, Marilda
Soares, Cristiane Nascimento
Lima, Marco Antonio Sales Dantas de
Leite, Ana Claudia Celestino Bezerra
Araujo, Abelardo Queiroz Campos
Brandão, Carlos Otávio
Silva, Marcus Tulius Teixeira
author_facet Espíndola, Otávio de Melo
Siqueira, Marilda
Soares, Cristiane Nascimento
Lima, Marco Antonio Sales Dantas de
Leite, Ana Claudia Celestino Bezerra
Araujo, Abelardo Queiroz Campos
Brandão, Carlos Otávio
Silva, Marcus Tulius Teixeira
author_sort Espíndola, Otávio de Melo
collection PubMed
description We report that patients with COVID-19 displaying distinct neurological disorders have undetectable or extremely low levels of SARS-CoV-2 RNA in the cerebrospinal fluid, indicating that viral clearance precede the neurological involvement. This finding points to the need for the development of more sensitive molecular tests and the investigation of other neurotropic pathogens to exclude concurrent neuroinfection.
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spelling pubmed-72718612020-06-05 Patients with COVID-19 and neurological manifestations show undetectable SARS-CoV-2 RNA levels in the cerebrospinal fluid Espíndola, Otávio de Melo Siqueira, Marilda Soares, Cristiane Nascimento Lima, Marco Antonio Sales Dantas de Leite, Ana Claudia Celestino Bezerra Araujo, Abelardo Queiroz Campos Brandão, Carlos Otávio Silva, Marcus Tulius Teixeira Int J Infect Dis Article We report that patients with COVID-19 displaying distinct neurological disorders have undetectable or extremely low levels of SARS-CoV-2 RNA in the cerebrospinal fluid, indicating that viral clearance precede the neurological involvement. This finding points to the need for the development of more sensitive molecular tests and the investigation of other neurotropic pathogens to exclude concurrent neuroinfection. The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. 2020-07 2020-06-04 /pmc/articles/PMC7271861/ /pubmed/32505878 http://dx.doi.org/10.1016/j.ijid.2020.05.123 Text en © 2020 The Author(s) Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Espíndola, Otávio de Melo
Siqueira, Marilda
Soares, Cristiane Nascimento
Lima, Marco Antonio Sales Dantas de
Leite, Ana Claudia Celestino Bezerra
Araujo, Abelardo Queiroz Campos
Brandão, Carlos Otávio
Silva, Marcus Tulius Teixeira
Patients with COVID-19 and neurological manifestations show undetectable SARS-CoV-2 RNA levels in the cerebrospinal fluid
title Patients with COVID-19 and neurological manifestations show undetectable SARS-CoV-2 RNA levels in the cerebrospinal fluid
title_full Patients with COVID-19 and neurological manifestations show undetectable SARS-CoV-2 RNA levels in the cerebrospinal fluid
title_fullStr Patients with COVID-19 and neurological manifestations show undetectable SARS-CoV-2 RNA levels in the cerebrospinal fluid
title_full_unstemmed Patients with COVID-19 and neurological manifestations show undetectable SARS-CoV-2 RNA levels in the cerebrospinal fluid
title_short Patients with COVID-19 and neurological manifestations show undetectable SARS-CoV-2 RNA levels in the cerebrospinal fluid
title_sort patients with covid-19 and neurological manifestations show undetectable sars-cov-2 rna levels in the cerebrospinal fluid
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271861/
https://www.ncbi.nlm.nih.gov/pubmed/32505878
http://dx.doi.org/10.1016/j.ijid.2020.05.123
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