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Independent inhibition of the polymerase and deubiquitinase activities of the Crimean-Congo Hemorrhagic Fever Virus full-length L-protein

BACKGROUND: The Crimean-Congo hemorrhagic fever virus (CCHFV) is a segmented negative-sense RNA virus that can cause severe human disease. The World Health Organization (WHO) has listed CCHFVas a priority pathogen with an urgent need for enhanced research activities to develop effective countermeasu...

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Detalles Bibliográficos
Autores principales: Tchesnokov, Egor P., Bailey-Elkin, Ben A., Mark, Brian L., Götte, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271988/
https://www.ncbi.nlm.nih.gov/pubmed/32497085
http://dx.doi.org/10.1371/journal.pntd.0008283