Beyond SNP heritability: Polygenicity and discoverability of phenotypes estimated with a univariate Gaussian mixture model

Estimating the polygenicity (proportion of causally associated single nucleotide polymorphisms (SNPs)) and discoverability (effect size variance) of causal SNPs for human traits is currently of considerable interest. SNP-heritability is proportional to the product of these quantities. We present a b...

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Detalles Bibliográficos
Autores principales: Holland, Dominic, Frei, Oleksandr, Desikan, Rahul, Fan, Chun-Chieh, Shadrin, Alexey A., Smeland, Olav B., Sundar, V. S., Thompson, Paul, Andreassen, Ole A., Dale, Anders M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7272101/
https://www.ncbi.nlm.nih.gov/pubmed/32427991
http://dx.doi.org/10.1371/journal.pgen.1008612

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