A facile sonochemical protocol for synthesis of 3-amino- and 4-amino-1,2,4-triazole derived Schiff bases as potential antibacterial agents

A facile method has been developed for the synthesis of Schiff bases derived from substituted and unsubstituted 3-amino- and 4-amino-1,2,4-triazoles. Condensation of the aminotrizoles with a variety of aromatic aldehydes afforded desired Schiff bases in excellent yields in 3–5 minutes of exposure to...

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Detalles Bibliográficos
Autores principales: Sultan, Aeysha, Ur Rehman, Mian Habib, Sajjad, Noreen, Irfan, Ali, Ullah, Irfan, Mustaqeem, Muhammad, Saleem, Muhammad, Rubab, Syeda Laila, Rafiq, Muhammad, Khalid, Muhammad, Kotwica-Mojzych, Katarzyna, Mojzych, Mariusz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7272133/
https://www.ncbi.nlm.nih.gov/pubmed/32497076
http://dx.doi.org/10.1371/journal.pone.0229891
Descripción
Sumario:A facile method has been developed for the synthesis of Schiff bases derived from substituted and unsubstituted 3-amino- and 4-amino-1,2,4-triazoles. Condensation of the aminotrizoles with a variety of aromatic aldehydes afforded desired Schiff bases in excellent yields in 3–5 minutes of exposure to ultra-sound. The synthesized compounds were characterized by means of IR, (1)HNMR and Mass spectrometry. The synthesized compounds were also screened for their antibacterial potential against Gram-negative (Escherichia coli, Shigella sonnei, Pseudomonas aeruginosa and Salmonella typhi) and two Gram-positive (Staphylococcus aureus and Bacillus subtilis) strains.

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