A facile sonochemical protocol for synthesis of 3-amino- and 4-amino-1,2,4-triazole derived Schiff bases as potential antibacterial agents

A facile method has been developed for the synthesis of Schiff bases derived from substituted and unsubstituted 3-amino- and 4-amino-1,2,4-triazoles. Condensation of the aminotrizoles with a variety of aromatic aldehydes afforded desired Schiff bases in excellent yields in 3–5 minutes of exposure to...

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Autores principales: Sultan, Aeysha, Ur Rehman, Mian Habib, Sajjad, Noreen, Irfan, Ali, Ullah, Irfan, Mustaqeem, Muhammad, Saleem, Muhammad, Rubab, Syeda Laila, Rafiq, Muhammad, Khalid, Muhammad, Kotwica-Mojzych, Katarzyna, Mojzych, Mariusz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
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Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7272133/
https://www.ncbi.nlm.nih.gov/pubmed/32497076
http://dx.doi.org/10.1371/journal.pone.0229891
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author Sultan, Aeysha
Ur Rehman, Mian Habib
Sajjad, Noreen
Irfan, Ali
Ullah, Irfan
Mustaqeem, Muhammad
Saleem, Muhammad
Rubab, Syeda Laila
Rafiq, Muhammad
Khalid, Muhammad
Kotwica-Mojzych, Katarzyna
Mojzych, Mariusz
author_facet Sultan, Aeysha
Ur Rehman, Mian Habib
Sajjad, Noreen
Irfan, Ali
Ullah, Irfan
Mustaqeem, Muhammad
Saleem, Muhammad
Rubab, Syeda Laila
Rafiq, Muhammad
Khalid, Muhammad
Kotwica-Mojzych, Katarzyna
Mojzych, Mariusz
author_sort Sultan, Aeysha
collection PubMed
description A facile method has been developed for the synthesis of Schiff bases derived from substituted and unsubstituted 3-amino- and 4-amino-1,2,4-triazoles. Condensation of the aminotrizoles with a variety of aromatic aldehydes afforded desired Schiff bases in excellent yields in 3–5 minutes of exposure to ultra-sound. The synthesized compounds were characterized by means of IR, (1)HNMR and Mass spectrometry. The synthesized compounds were also screened for their antibacterial potential against Gram-negative (Escherichia coli, Shigella sonnei, Pseudomonas aeruginosa and Salmonella typhi) and two Gram-positive (Staphylococcus aureus and Bacillus subtilis) strains.
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spelling pubmed-72721332020-06-09 A facile sonochemical protocol for synthesis of 3-amino- and 4-amino-1,2,4-triazole derived Schiff bases as potential antibacterial agents Sultan, Aeysha Ur Rehman, Mian Habib Sajjad, Noreen Irfan, Ali Ullah, Irfan Mustaqeem, Muhammad Saleem, Muhammad Rubab, Syeda Laila Rafiq, Muhammad Khalid, Muhammad Kotwica-Mojzych, Katarzyna Mojzych, Mariusz PLoS One Research Article A facile method has been developed for the synthesis of Schiff bases derived from substituted and unsubstituted 3-amino- and 4-amino-1,2,4-triazoles. Condensation of the aminotrizoles with a variety of aromatic aldehydes afforded desired Schiff bases in excellent yields in 3–5 minutes of exposure to ultra-sound. The synthesized compounds were characterized by means of IR, (1)HNMR and Mass spectrometry. The synthesized compounds were also screened for their antibacterial potential against Gram-negative (Escherichia coli, Shigella sonnei, Pseudomonas aeruginosa and Salmonella typhi) and two Gram-positive (Staphylococcus aureus and Bacillus subtilis) strains. Public Library of Science 2020-06-04 /pmc/articles/PMC7272133/ /pubmed/32497076 http://dx.doi.org/10.1371/journal.pone.0229891 Text en © 2020 Sultan et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Sultan, Aeysha
Ur Rehman, Mian Habib
Sajjad, Noreen
Irfan, Ali
Ullah, Irfan
Mustaqeem, Muhammad
Saleem, Muhammad
Rubab, Syeda Laila
Rafiq, Muhammad
Khalid, Muhammad
Kotwica-Mojzych, Katarzyna
Mojzych, Mariusz
A facile sonochemical protocol for synthesis of 3-amino- and 4-amino-1,2,4-triazole derived Schiff bases as potential antibacterial agents
title A facile sonochemical protocol for synthesis of 3-amino- and 4-amino-1,2,4-triazole derived Schiff bases as potential antibacterial agents
title_full A facile sonochemical protocol for synthesis of 3-amino- and 4-amino-1,2,4-triazole derived Schiff bases as potential antibacterial agents
title_fullStr A facile sonochemical protocol for synthesis of 3-amino- and 4-amino-1,2,4-triazole derived Schiff bases as potential antibacterial agents
title_full_unstemmed A facile sonochemical protocol for synthesis of 3-amino- and 4-amino-1,2,4-triazole derived Schiff bases as potential antibacterial agents
title_short A facile sonochemical protocol for synthesis of 3-amino- and 4-amino-1,2,4-triazole derived Schiff bases as potential antibacterial agents
title_sort facile sonochemical protocol for synthesis of 3-amino- and 4-amino-1,2,4-triazole derived schiff bases as potential antibacterial agents
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7272133/
https://www.ncbi.nlm.nih.gov/pubmed/32497076
http://dx.doi.org/10.1371/journal.pone.0229891
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