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Bridging integrator 1 protein loss in Alzheimer’s disease promotes synaptic tau accumulation and disrupts tau release

Polymorphisms associated with BIN1 (bridging integrator 1) confer the second greatest risk for developing late-onset Alzheimer’s disease. The biological consequences of this genetic variation are not fully understood; however, BIN1 is a binding partner for tau. Tau is normally a highly soluble cytop...

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Detalles Bibliográficos
Autores principales:	Glennon, Elizabeth B, Lau, Dawn H W, Gabriele, Rebecca M C, Taylor, Matthew F, Troakes, Claire, Opie-Martin, Sarah, Elliott, Christina, Killick, Richard, Hanger, Diane P, Perez-Nievas, Beatriz G, Noble, Wendy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7272218/ https://www.ncbi.nlm.nih.gov/pubmed/32500121 http://dx.doi.org/10.1093/braincomms/fcaa011

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