T1D progression is associated with loss of CD3(+)CD56(+) regulatory T cells that control CD8(+) T cell effector functions

An unresolved issue in autoimmunity is the lack of surrogate biomarkers of immunological self-tolerance for disease monitoring. Here, we show that peripheral frequency of a regulatory T cell population, characterized by the co-expression of CD3 and CD56 molecules (T(R3-56)), is reduced in subjects w...

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Detalles Bibliográficos
Autores principales: Terrazzano, Giuseppe, Bruzzaniti, Sara, Rubino, Valentina, Santopaolo, Marianna, Palatucci, Anna Teresa, Giovazzino, Angela, La Rocca, Claudia, de Candia, Paola, Puca, Annibale, Perna, Francesco, Procaccini, Claudio, De Rosa, Veronica, Porcellini, Chiara, De Simone, Salvatore, Fattorusso, Valentina, Porcellini, Antonio, Mozzillo, Enza, Troncone, Riccardo, Franzese, Adriana, Ludvigsson, Johnny, Matarese, Giuseppe, Ruggiero, Giuseppina, Galgani, Mario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7272221/
https://www.ncbi.nlm.nih.gov/pubmed/32500117
http://dx.doi.org/10.1038/s42255-020-0173-1

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