An essential role for Argonaute 2 in EGFR-KRAS signaling in pancreatic cancer development

Both KRAS and EGFR are essential mediators of pancreatic cancer development and interact with Argonaute 2 (AGO2) to perturb its function. Here, in a mouse model of mutant KRAS-driven pancreatic cancer, loss of AGO2 allows precursor lesion (PanIN) formation yet prevents progression to pancreatic duct...

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Detalles Bibliográficos
Autores principales: Shankar, Sunita, Tien, Jean Ching-Yi, Siebenaler, Ronald F., Chugh, Seema, Dommeti, Vijaya L., Zelenka-Wang, Sylvia, Wang, Xiao-Ming, Apel, Ingrid J., Waninger, Jessica, Eyunni, Sanjana, Xu, Alice, Mody, Malay, Goodrum, Andrew, Zhang, Yuping, Tesmer, John J., Mannan, Rahul, Cao, Xuhong, Vats, Pankaj, Pitchiaya, Sethuramasundaram, Ellison, Stephanie J., Shi, Jiaqi, Kumar-Sinha, Chandan, Crawford, Howard C., Chinnaiyan, Arul M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7272436/
https://www.ncbi.nlm.nih.gov/pubmed/32499547
http://dx.doi.org/10.1038/s41467-020-16309-2

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