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Physicochemical-guided design of cathelicidin-derived peptides generates membrane active variants with therapeutic potential
The spread of multi-drug resistance and the slow pace at which antibiotics come onto the market are undermining our ability to treat human infections, leading to high mortality rates. Aiming to overcome this global crisis, antimicrobial peptides are considered promising alternatives to counter bacte...
Autores principales: | Oliveira, Nelson G. J., Cardoso, Marlon H., Velikova, Nadya, Giesbers, Marcel, Wells, Jerry M., Rezende, Taia M. B., de Vries, Renko, Franco, Octávio L. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7272458/ https://www.ncbi.nlm.nih.gov/pubmed/32499582 http://dx.doi.org/10.1038/s41598-020-66164-w |
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