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Genoprotective activities of plant natural substances in cancer and chemopreventive strategies in the context of 3P medicine

Severe durable changes may occur to the DNA structure caused by exogenous and endogenous risk factors initiating the process of carcinogenesis. By evidence, a large portion of malignancies have been demonstrated as being preventable. Moreover, the targeted prevention of cancer onset is possible, due...

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Autores principales: Koklesova, Lenka, Liskova, Alena, Samec, Marek, Qaradakhi, Tawar, Zulli, Anthony, Smejkal, Karel, Kajo, Karol, Jakubikova, Jana, Behzadi, Payam, Pec, Martin, Zubor, Pavol, Biringer, Kamil, Kwon, Taeg Kyu, Büsselberg, Dietrich, Sarria, Gustavo R., Giordano, Frank A., Golubnitschaja, Olga, Kubatka, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7272522/
https://www.ncbi.nlm.nih.gov/pubmed/32547652
http://dx.doi.org/10.1007/s13167-020-00210-5
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author Koklesova, Lenka
Liskova, Alena
Samec, Marek
Qaradakhi, Tawar
Zulli, Anthony
Smejkal, Karel
Kajo, Karol
Jakubikova, Jana
Behzadi, Payam
Pec, Martin
Zubor, Pavol
Biringer, Kamil
Kwon, Taeg Kyu
Büsselberg, Dietrich
Sarria, Gustavo R.
Giordano, Frank A.
Golubnitschaja, Olga
Kubatka, Peter
author_facet Koklesova, Lenka
Liskova, Alena
Samec, Marek
Qaradakhi, Tawar
Zulli, Anthony
Smejkal, Karel
Kajo, Karol
Jakubikova, Jana
Behzadi, Payam
Pec, Martin
Zubor, Pavol
Biringer, Kamil
Kwon, Taeg Kyu
Büsselberg, Dietrich
Sarria, Gustavo R.
Giordano, Frank A.
Golubnitschaja, Olga
Kubatka, Peter
author_sort Koklesova, Lenka
collection PubMed
description Severe durable changes may occur to the DNA structure caused by exogenous and endogenous risk factors initiating the process of carcinogenesis. By evidence, a large portion of malignancies have been demonstrated as being preventable. Moreover, the targeted prevention of cancer onset is possible, due to unique properties of plant bioactive compounds. Although genoprotective effects of phytochemicals have been well documented, there is an evident lack of articles which would systematically present the spectrum of anticancer effects by phytochemicals, plant extracts, and plant-derived diet applicable to stratified patient groups at the level of targeted primary (cancer development) and secondary (cancer progression and metastatic disease) prevention. Consequently, clinical implementation of knowledge accumulated in the area is still highly restricted. To stimulate coherent co-development of the dedicated plant bioactive compound investigation on one hand and comprehensive cancer preventive strategies on the other hand, the current paper highlights and deeply analyses relevant evidence available in the area. Key molecular mechanisms are presented to detail genoprotective and anticancer activities of plants and phytochemicals. Clinical implementation is discussed. Based on the presented evidence, advanced chemopreventive strategies in the context of 3P medicine are considered.
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spelling pubmed-72725222020-06-15 Genoprotective activities of plant natural substances in cancer and chemopreventive strategies in the context of 3P medicine Koklesova, Lenka Liskova, Alena Samec, Marek Qaradakhi, Tawar Zulli, Anthony Smejkal, Karel Kajo, Karol Jakubikova, Jana Behzadi, Payam Pec, Martin Zubor, Pavol Biringer, Kamil Kwon, Taeg Kyu Büsselberg, Dietrich Sarria, Gustavo R. Giordano, Frank A. Golubnitschaja, Olga Kubatka, Peter EPMA J Review Severe durable changes may occur to the DNA structure caused by exogenous and endogenous risk factors initiating the process of carcinogenesis. By evidence, a large portion of malignancies have been demonstrated as being preventable. Moreover, the targeted prevention of cancer onset is possible, due to unique properties of plant bioactive compounds. Although genoprotective effects of phytochemicals have been well documented, there is an evident lack of articles which would systematically present the spectrum of anticancer effects by phytochemicals, plant extracts, and plant-derived diet applicable to stratified patient groups at the level of targeted primary (cancer development) and secondary (cancer progression and metastatic disease) prevention. Consequently, clinical implementation of knowledge accumulated in the area is still highly restricted. To stimulate coherent co-development of the dedicated plant bioactive compound investigation on one hand and comprehensive cancer preventive strategies on the other hand, the current paper highlights and deeply analyses relevant evidence available in the area. Key molecular mechanisms are presented to detail genoprotective and anticancer activities of plants and phytochemicals. Clinical implementation is discussed. Based on the presented evidence, advanced chemopreventive strategies in the context of 3P medicine are considered. Springer International Publishing 2020-05-29 /pmc/articles/PMC7272522/ /pubmed/32547652 http://dx.doi.org/10.1007/s13167-020-00210-5 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review
Koklesova, Lenka
Liskova, Alena
Samec, Marek
Qaradakhi, Tawar
Zulli, Anthony
Smejkal, Karel
Kajo, Karol
Jakubikova, Jana
Behzadi, Payam
Pec, Martin
Zubor, Pavol
Biringer, Kamil
Kwon, Taeg Kyu
Büsselberg, Dietrich
Sarria, Gustavo R.
Giordano, Frank A.
Golubnitschaja, Olga
Kubatka, Peter
Genoprotective activities of plant natural substances in cancer and chemopreventive strategies in the context of 3P medicine
title Genoprotective activities of plant natural substances in cancer and chemopreventive strategies in the context of 3P medicine
title_full Genoprotective activities of plant natural substances in cancer and chemopreventive strategies in the context of 3P medicine
title_fullStr Genoprotective activities of plant natural substances in cancer and chemopreventive strategies in the context of 3P medicine
title_full_unstemmed Genoprotective activities of plant natural substances in cancer and chemopreventive strategies in the context of 3P medicine
title_short Genoprotective activities of plant natural substances in cancer and chemopreventive strategies in the context of 3P medicine
title_sort genoprotective activities of plant natural substances in cancer and chemopreventive strategies in the context of 3p medicine
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7272522/
https://www.ncbi.nlm.nih.gov/pubmed/32547652
http://dx.doi.org/10.1007/s13167-020-00210-5
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