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Effect of Down syndrome and keratoconus on corneal density and volume: a triple comparative study

Keratoconus (KCN) and Down syndrome affect the corneal density and volume. In this study included Down syndrome patients with and without KCN (24 Down-KCN and 204 Down-nonKCN eyes) and normal age- and gender-matched individuals (184 eyes). Studied parameters were the corneal density measured with Pe...

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Autores principales: Asgari, Soheila, Aghamirsalim, Mohammadreza, Mehravaran, Shiva, Hashemi, Hassan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7272627/
https://www.ncbi.nlm.nih.gov/pubmed/32499561
http://dx.doi.org/10.1038/s41598-020-66108-4
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author Asgari, Soheila
Aghamirsalim, Mohammadreza
Mehravaran, Shiva
Hashemi, Hassan
author_facet Asgari, Soheila
Aghamirsalim, Mohammadreza
Mehravaran, Shiva
Hashemi, Hassan
author_sort Asgari, Soheila
collection PubMed
description Keratoconus (KCN) and Down syndrome affect the corneal density and volume. In this study included Down syndrome patients with and without KCN (24 Down-KCN and 204 Down-nonKCN eyes) and normal age- and gender-matched individuals (184 eyes). Studied parameters were the corneal density measured with Pentacam HR in 5 concentric zones and annuli (0–2 mm, 2–6 mm, 6–10 mm, 10–12 mm, and 0–12 mm) in 4 different depth layers (anterior 120 µm, posterior 60 µm, middle layer, and the full thickness of the cornea), and the 10 mm zone corneal volume. In Down-KCN, Down-nonKCN, and control groups, respectively, mean full thickness density in the 0–12 mm zone was 19.35 ± 2.92, 17.85 ± 2.55, and 15.78 ± 2.67 GSU, and mean corneal volume was 57.45 ± 4.37, 56.99 ± 3.46, and 61.43 ± 3.42mm(3). All density readings were significantly different between the three studied groups (all P < 0.01) except full thickness density in 0–2 mm and 2–6 mm (P > 0.05) and corneal volume (P = 0.519) between Down-KCN and Down-nonKCN groups; these inter-group densitometry differences within the 6 mm zone were only in the middle layer, and not the anterior or posterior thickness layers (all P > 0.05). Corneal density increased with age and corneal thickness, but there was no significant relationship with gender. Overall, Down syndrome is associated with increased density and light scatter in all corneal layers up to the 12 mm diameter. In Down patients with KCN, the increased light scatter and density in the 6 mm zone is only in the middle thickness layer. Corneal volume is reduced in Down syndrome irrespective of the presence or absence of KCN.
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spelling pubmed-72726272020-06-05 Effect of Down syndrome and keratoconus on corneal density and volume: a triple comparative study Asgari, Soheila Aghamirsalim, Mohammadreza Mehravaran, Shiva Hashemi, Hassan Sci Rep Article Keratoconus (KCN) and Down syndrome affect the corneal density and volume. In this study included Down syndrome patients with and without KCN (24 Down-KCN and 204 Down-nonKCN eyes) and normal age- and gender-matched individuals (184 eyes). Studied parameters were the corneal density measured with Pentacam HR in 5 concentric zones and annuli (0–2 mm, 2–6 mm, 6–10 mm, 10–12 mm, and 0–12 mm) in 4 different depth layers (anterior 120 µm, posterior 60 µm, middle layer, and the full thickness of the cornea), and the 10 mm zone corneal volume. In Down-KCN, Down-nonKCN, and control groups, respectively, mean full thickness density in the 0–12 mm zone was 19.35 ± 2.92, 17.85 ± 2.55, and 15.78 ± 2.67 GSU, and mean corneal volume was 57.45 ± 4.37, 56.99 ± 3.46, and 61.43 ± 3.42mm(3). All density readings were significantly different between the three studied groups (all P < 0.01) except full thickness density in 0–2 mm and 2–6 mm (P > 0.05) and corneal volume (P = 0.519) between Down-KCN and Down-nonKCN groups; these inter-group densitometry differences within the 6 mm zone were only in the middle layer, and not the anterior or posterior thickness layers (all P > 0.05). Corneal density increased with age and corneal thickness, but there was no significant relationship with gender. Overall, Down syndrome is associated with increased density and light scatter in all corneal layers up to the 12 mm diameter. In Down patients with KCN, the increased light scatter and density in the 6 mm zone is only in the middle thickness layer. Corneal volume is reduced in Down syndrome irrespective of the presence or absence of KCN. Nature Publishing Group UK 2020-06-04 /pmc/articles/PMC7272627/ /pubmed/32499561 http://dx.doi.org/10.1038/s41598-020-66108-4 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Asgari, Soheila
Aghamirsalim, Mohammadreza
Mehravaran, Shiva
Hashemi, Hassan
Effect of Down syndrome and keratoconus on corneal density and volume: a triple comparative study
title Effect of Down syndrome and keratoconus on corneal density and volume: a triple comparative study
title_full Effect of Down syndrome and keratoconus on corneal density and volume: a triple comparative study
title_fullStr Effect of Down syndrome and keratoconus on corneal density and volume: a triple comparative study
title_full_unstemmed Effect of Down syndrome and keratoconus on corneal density and volume: a triple comparative study
title_short Effect of Down syndrome and keratoconus on corneal density and volume: a triple comparative study
title_sort effect of down syndrome and keratoconus on corneal density and volume: a triple comparative study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7272627/
https://www.ncbi.nlm.nih.gov/pubmed/32499561
http://dx.doi.org/10.1038/s41598-020-66108-4
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