REV7 is required for processing AID initiated DNA lesions in activated B cells

Activation-induced cytidine deaminase (AID) initiates both antibody class switch recombination (CSR) and somatic hypermutation (SHM) in antibody diversification. DNA double-strand break response (DSBR) factors promote rearrangement in CSR, while translesion synthesis (TLS) polymerases generate mutat...

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Detalles Bibliográficos
Autores principales: Yang, Dingpeng, Sun, Ying, Chen, Jingjing, Zhang, Ying, Fan, Shuangshuang, Huang, Min, Xie, Xia, Cai, Yanni, Shang, Yafang, Gui, Tuantuan, Sun, Liming, Hu, Jiazhi, Dong, Junchao, Yeap, Leng-Siew, Wang, Xiaoming, Xiao, Wei, Meng, Fei-Long
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7272641/
https://www.ncbi.nlm.nih.gov/pubmed/32499490
http://dx.doi.org/10.1038/s41467-020-16632-8

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