Pericyte FAK negatively regulates Gas6/Axl signalling to suppress tumour angiogenesis and tumour growth

The overexpression of the protein tyrosine kinase, Focal adhesion kinase (FAK), in endothelial cells has implicated its requirement in angiogenesis and tumour growth, but how pericyte FAK regulates tumour angiogenesis is unknown. We show that pericyte FAK regulates tumour growth and angiogenesis in...

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Detalles Bibliográficos
Autores principales: Lechertier, Tanguy, Reynolds, Louise E., Kim, Hyojin, Pedrosa, Ana Rita, Gómez-Escudero, Jesús, Muñoz-Félix, José M., Batista, Silvia, Dukinfield, Matthew, Demircioglu, Fevzi, Wong, Ping Pui, Matchett, Kylie P., Henderson, Neil C., D’Amico, Gabriela, Parsons, Maddy, Harwood, Catherine, Meier, Pascal, Hodivala-Dilke, Kairbaan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7272651/
https://www.ncbi.nlm.nih.gov/pubmed/32499572
http://dx.doi.org/10.1038/s41467-020-16618-6

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