Human aminolevulinate synthase structure reveals a eukaryotic-specific autoinhibitory loop regulating substrate binding and product release

5′-aminolevulinate synthase (ALAS) catalyzes the first step in heme biosynthesis, generating 5′-aminolevulinate from glycine and succinyl-CoA. Inherited frameshift indel mutations of human erythroid-specific isozyme ALAS2, within a C-terminal (Ct) extension of its catalytic core that is only present...

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Detalles Bibliográficos
Autores principales: Bailey, Henry J., Bezerra, Gustavo A., Marcero, Jason R., Padhi, Siladitya, Foster, William R., Rembeza, Elzbieta, Roy, Arijit, Bishop, David F., Desnick, Robert J., Bulusu, Gopalakrishnan, Dailey, Harry A., Yue, Wyatt W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7272653/
https://www.ncbi.nlm.nih.gov/pubmed/32499479
http://dx.doi.org/10.1038/s41467-020-16586-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7272653/
https://www.ncbi.nlm.nih.gov/pubmed/32499479
http://dx.doi.org/10.1038/s41467-020-16586-x

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