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Neuron-autonomous susceptibility to induced synuclein aggregation is exacerbated by endogenous Lrrk2 mutations and ameliorated by Lrrk2 genetic knock-out

Neuronal aggregates containing α-synuclein are a pathological hallmark of several degenerative diseases; including Parkinson’s disease, Parkinson’s disease with dementia and dementia with Lewy bodies. Understanding the process of α-synuclein aggregation, and discovering means of preventing it, may h...

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Detalles Bibliográficos
Autores principales:	MacIsaac, Sarah, Quevedo Melo, Thaiany, Zhang, Yuting, Volta, Mattia, Farrer, Matthew J, Milnerwood, Austen J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7273240/ https://www.ncbi.nlm.nih.gov/pubmed/32510053 http://dx.doi.org/10.1093/braincomms/fcz052

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