SARS-CoV-2 seroprevalence and neutralizing activity in donor and patient blood from the San Francisco Bay Area

We report very low SARS-CoV-2 seroprevalence in two San Francisco Bay Area populations. Seropositivity was 0.26% in 387 hospitalized patients admitted for non-respiratory indications and 0.1% in 1,000 blood donors. We additionally describe the longitudinal dynamics of immunoglobulin-G, immunoglobuli...

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Detalles Bibliográficos
Autores principales: Ng, Dianna L., Goldgof, Gregory M., Shy, Brian R., Levine, Andrew G., Balcerek, Joanna, Bapat, Sagar P., Prostko, John, Rodgers, Mary, Coller, Kelly, Pearce, Sandy, Franz, Sergej, Du, Li, Stone, Mars, Pillai, Satish K., Sotomayor-Gonzalez, Alicia, Servellita, Venice, Martin, Claudia Sanchez San, Granados, Andrea, Glasner, Dustin R., Han, Lucy M., Truong, Kent, Akagi, Naomi, Nguyen, David N., Neumann, Neil M., Qazi, Daniel, Hsu, Elaine, Gu, Wei, Santos, Yale A., Custer, Brian, Green, Valerie, Williamson, Phillip, Hills, Nancy K., Lu, Chuanyi M., Whitman, Jeffrey D., Stramer, Susan, Wang, Candace, Reyes, Kevin, Hakim, Jill M.C., Sujishi, Kirk, Alazzeh, Fariba, Pham, Lori, Oon, Ching-Ying, Miller, Steve, Kurtz, Theodore, Hackett, John, Simmons, Graham, Busch, Michael P., Chiu, Charles Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7273245/
https://www.ncbi.nlm.nih.gov/pubmed/32511477
http://dx.doi.org/10.1101/2020.05.19.20107482
Descripción
Sumario:We report very low SARS-CoV-2 seroprevalence in two San Francisco Bay Area populations. Seropositivity was 0.26% in 387 hospitalized patients admitted for non-respiratory indications and 0.1% in 1,000 blood donors. We additionally describe the longitudinal dynamics of immunoglobulin-G, immunoglobulin-M, and in vitro neutralizing antibody titers in COVID-19 patients. Neutralizing antibodies rise in tandem with immunoglobulin levels following symptom onset, exhibiting median time to seroconversion within one day of each other, and there is >93% positive percent agreement between detection of immunoglobulin-G and neutralizing titers.

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