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SARS-CoV-2 seroprevalence and neutralizing activity in donor and patient blood from the San Francisco Bay Area
We report very low SARS-CoV-2 seroprevalence in two San Francisco Bay Area populations. Seropositivity was 0.26% in 387 hospitalized patients admitted for non-respiratory indications and 0.1% in 1,000 blood donors. We additionally describe the longitudinal dynamics of immunoglobulin-G, immunoglobuli...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cold Spring Harbor Laboratory
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7273245/ https://www.ncbi.nlm.nih.gov/pubmed/32511477 http://dx.doi.org/10.1101/2020.05.19.20107482 |
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| author | Ng, Dianna L. Goldgof, Gregory M. Shy, Brian R. Levine, Andrew G. Balcerek, Joanna Bapat, Sagar P. Prostko, John Rodgers, Mary Coller, Kelly Pearce, Sandy Franz, Sergej Du, Li Stone, Mars Pillai, Satish K. Sotomayor-Gonzalez, Alicia Servellita, Venice Martin, Claudia Sanchez San Granados, Andrea Glasner, Dustin R. Han, Lucy M. Truong, Kent Akagi, Naomi Nguyen, David N. Neumann, Neil M. Qazi, Daniel Hsu, Elaine Gu, Wei Santos, Yale A. Custer, Brian Green, Valerie Williamson, Phillip Hills, Nancy K. Lu, Chuanyi M. Whitman, Jeffrey D. Stramer, Susan Wang, Candace Reyes, Kevin Hakim, Jill M.C. Sujishi, Kirk Alazzeh, Fariba Pham, Lori Oon, Ching-Ying Miller, Steve Kurtz, Theodore Hackett, John Simmons, Graham Busch, Michael P. Chiu, Charles Y. |
| author_facet | Ng, Dianna L. Goldgof, Gregory M. Shy, Brian R. Levine, Andrew G. Balcerek, Joanna Bapat, Sagar P. Prostko, John Rodgers, Mary Coller, Kelly Pearce, Sandy Franz, Sergej Du, Li Stone, Mars Pillai, Satish K. Sotomayor-Gonzalez, Alicia Servellita, Venice Martin, Claudia Sanchez San Granados, Andrea Glasner, Dustin R. Han, Lucy M. Truong, Kent Akagi, Naomi Nguyen, David N. Neumann, Neil M. Qazi, Daniel Hsu, Elaine Gu, Wei Santos, Yale A. Custer, Brian Green, Valerie Williamson, Phillip Hills, Nancy K. Lu, Chuanyi M. Whitman, Jeffrey D. Stramer, Susan Wang, Candace Reyes, Kevin Hakim, Jill M.C. Sujishi, Kirk Alazzeh, Fariba Pham, Lori Oon, Ching-Ying Miller, Steve Kurtz, Theodore Hackett, John Simmons, Graham Busch, Michael P. Chiu, Charles Y. |
| author_sort | Ng, Dianna L. |
| collection | PubMed |
| description | We report very low SARS-CoV-2 seroprevalence in two San Francisco Bay Area populations. Seropositivity was 0.26% in 387 hospitalized patients admitted for non-respiratory indications and 0.1% in 1,000 blood donors. We additionally describe the longitudinal dynamics of immunoglobulin-G, immunoglobulin-M, and in vitro neutralizing antibody titers in COVID-19 patients. Neutralizing antibodies rise in tandem with immunoglobulin levels following symptom onset, exhibiting median time to seroconversion within one day of each other, and there is >93% positive percent agreement between detection of immunoglobulin-G and neutralizing titers. |
| format | Online Article Text |
| id | pubmed-7273245 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2020 |
| publisher | Cold Spring Harbor Laboratory |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-72732452020-06-07 SARS-CoV-2 seroprevalence and neutralizing activity in donor and patient blood from the San Francisco Bay Area Ng, Dianna L. Goldgof, Gregory M. Shy, Brian R. Levine, Andrew G. Balcerek, Joanna Bapat, Sagar P. Prostko, John Rodgers, Mary Coller, Kelly Pearce, Sandy Franz, Sergej Du, Li Stone, Mars Pillai, Satish K. Sotomayor-Gonzalez, Alicia Servellita, Venice Martin, Claudia Sanchez San Granados, Andrea Glasner, Dustin R. Han, Lucy M. Truong, Kent Akagi, Naomi Nguyen, David N. Neumann, Neil M. Qazi, Daniel Hsu, Elaine Gu, Wei Santos, Yale A. Custer, Brian Green, Valerie Williamson, Phillip Hills, Nancy K. Lu, Chuanyi M. Whitman, Jeffrey D. Stramer, Susan Wang, Candace Reyes, Kevin Hakim, Jill M.C. Sujishi, Kirk Alazzeh, Fariba Pham, Lori Oon, Ching-Ying Miller, Steve Kurtz, Theodore Hackett, John Simmons, Graham Busch, Michael P. Chiu, Charles Y. medRxiv Article We report very low SARS-CoV-2 seroprevalence in two San Francisco Bay Area populations. Seropositivity was 0.26% in 387 hospitalized patients admitted for non-respiratory indications and 0.1% in 1,000 blood donors. We additionally describe the longitudinal dynamics of immunoglobulin-G, immunoglobulin-M, and in vitro neutralizing antibody titers in COVID-19 patients. Neutralizing antibodies rise in tandem with immunoglobulin levels following symptom onset, exhibiting median time to seroconversion within one day of each other, and there is >93% positive percent agreement between detection of immunoglobulin-G and neutralizing titers. Cold Spring Harbor Laboratory 2020-05-27 /pmc/articles/PMC7273245/ /pubmed/32511477 http://dx.doi.org/10.1101/2020.05.19.20107482 Text en http://creativecommons.org/licenses/by-nc-nd/4.0/It is made available under a CC-BY-NC-ND 4.0 International license (http://creativecommons.org/licenses/by-nc-nd/4.0/) . |
| spellingShingle | Article Ng, Dianna L. Goldgof, Gregory M. Shy, Brian R. Levine, Andrew G. Balcerek, Joanna Bapat, Sagar P. Prostko, John Rodgers, Mary Coller, Kelly Pearce, Sandy Franz, Sergej Du, Li Stone, Mars Pillai, Satish K. Sotomayor-Gonzalez, Alicia Servellita, Venice Martin, Claudia Sanchez San Granados, Andrea Glasner, Dustin R. Han, Lucy M. Truong, Kent Akagi, Naomi Nguyen, David N. Neumann, Neil M. Qazi, Daniel Hsu, Elaine Gu, Wei Santos, Yale A. Custer, Brian Green, Valerie Williamson, Phillip Hills, Nancy K. Lu, Chuanyi M. Whitman, Jeffrey D. Stramer, Susan Wang, Candace Reyes, Kevin Hakim, Jill M.C. Sujishi, Kirk Alazzeh, Fariba Pham, Lori Oon, Ching-Ying Miller, Steve Kurtz, Theodore Hackett, John Simmons, Graham Busch, Michael P. Chiu, Charles Y. SARS-CoV-2 seroprevalence and neutralizing activity in donor and patient blood from the San Francisco Bay Area |
| title | SARS-CoV-2 seroprevalence and neutralizing activity in donor and patient blood from the San Francisco Bay Area |
| title_full | SARS-CoV-2 seroprevalence and neutralizing activity in donor and patient blood from the San Francisco Bay Area |
| title_fullStr | SARS-CoV-2 seroprevalence and neutralizing activity in donor and patient blood from the San Francisco Bay Area |
| title_full_unstemmed | SARS-CoV-2 seroprevalence and neutralizing activity in donor and patient blood from the San Francisco Bay Area |
| title_short | SARS-CoV-2 seroprevalence and neutralizing activity in donor and patient blood from the San Francisco Bay Area |
| title_sort | sars-cov-2 seroprevalence and neutralizing activity in donor and patient blood from the san francisco bay area |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7273245/ https://www.ncbi.nlm.nih.gov/pubmed/32511477 http://dx.doi.org/10.1101/2020.05.19.20107482 |
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