Robust ACE2 protein expression localizes to the motile cilia of the respiratory tract epithelia and is not increased by ACE inhibitors or angiotensin receptor blockers

We investigated the expression and subcellular localization of the SARS-CoV-2 receptor, angiotensin-converting enzyme 2 (ACE2), within the upper (nasal) and lower (pulmonary) respiratory tracts of healthy human donors. We detected ACE2 protein expression within the cilia organelle of ciliated airway...

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Detalles Bibliográficos
Autores principales: Lee, Ivan T., Nakayama, Tsuguhisa, Wu, Chien-Ting, Goltsev, Yury, Jiang, Sizun, Gall, Phillip A., Liao, Chun-Kang, Shih, Liang-Chun, Schürch, Christian M., McIlwain, David R., Chu, Pauline, Borchard, Nicole A., Zarabanda, David, Dholakia, Sachi S., Yang, Angela, Kim, Dayoung, Kanie, Tomoharu, Lin, Chia-Der, Tsai, Ming-Hsui, Phillips, Katie M., Kim, Raymond, Overdevest, Jonathan B., Tyler, Matthew A., Yan, Carol H., Lin, Chih-Feng, Lin, Yi-Tsen, Bau, Da-Tian, Tsay, Gregory J., Patel, Zara M., Tsou, Yung-An, Tai, Chih-Jaan, Yeh, Te-Huei, Hwang, Peter H., Nolan, Garry P., Nayak, Jayakar V., Jackson, Peter K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7273284/
https://www.ncbi.nlm.nih.gov/pubmed/32511516
http://dx.doi.org/10.1101/2020.05.08.20092866

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