PTPIP51 crosslinks the NFκB signaling and the MAPK pathway in SKBR3 cells

AIM: PTPIP51 interacts with NFκB signaling at the RelA and IκB level. NFκB signaling is linked to the initiation, progression and metastasis of breast cancer. Her2-amplified breast cancer cells frequently display activation of the NFκB signaling. We aimed to clarify the effects of NFκB inhibition on...

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Autores principales: Dietel, Eric, Brobeil, Alexander, Tag, Claudia, Gattenloehner, Stefan, Wimmer, Monika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Science Ltd 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7273389/
https://www.ncbi.nlm.nih.gov/pubmed/32518680
http://dx.doi.org/10.2144/fsoa-2019-0136
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author Dietel, Eric
Brobeil, Alexander
Tag, Claudia
Gattenloehner, Stefan
Wimmer, Monika
author_facet Dietel, Eric
Brobeil, Alexander
Tag, Claudia
Gattenloehner, Stefan
Wimmer, Monika
author_sort Dietel, Eric
collection PubMed
description AIM: PTPIP51 interacts with NFκB signaling at the RelA and IκB level. NFκB signaling is linked to the initiation, progression and metastasis of breast cancer. Her2-amplified breast cancer cells frequently display activation of the NFκB signaling. We aimed to clarify the effects of NFκB inhibition on the NFκB- and MAPK-related interactome of PTPIP51 and cell viability in HaCat cells and SKBR3 cells. RESULTS: IKK-16 selectively reduced cell viability in SKBR3 cells. PDTC induced a formation of the Raf1/14-3-3/PTPIP51 complex in SKBR3 cells, indicating a shift of PTPIP51 into MAPK signaling. CONCLUSION: IKK-16 selectively inhibits cell viability of SKBR3 cells. In addition, PTPIP51 might serve as the mediator between NFκB signaling and the MAPK pathway in SKBR3.
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spelling pubmed-72733892020-06-08 PTPIP51 crosslinks the NFκB signaling and the MAPK pathway in SKBR3 cells Dietel, Eric Brobeil, Alexander Tag, Claudia Gattenloehner, Stefan Wimmer, Monika Future Sci OA Research Article AIM: PTPIP51 interacts with NFκB signaling at the RelA and IκB level. NFκB signaling is linked to the initiation, progression and metastasis of breast cancer. Her2-amplified breast cancer cells frequently display activation of the NFκB signaling. We aimed to clarify the effects of NFκB inhibition on the NFκB- and MAPK-related interactome of PTPIP51 and cell viability in HaCat cells and SKBR3 cells. RESULTS: IKK-16 selectively reduced cell viability in SKBR3 cells. PDTC induced a formation of the Raf1/14-3-3/PTPIP51 complex in SKBR3 cells, indicating a shift of PTPIP51 into MAPK signaling. CONCLUSION: IKK-16 selectively inhibits cell viability of SKBR3 cells. In addition, PTPIP51 might serve as the mediator between NFκB signaling and the MAPK pathway in SKBR3. Future Science Ltd 2020-03-04 /pmc/articles/PMC7273389/ /pubmed/32518680 http://dx.doi.org/10.2144/fsoa-2019-0136 Text en © 2020 Eric Dietel This work is licensed under the Creative Commons Attribution 4.0 License (http://creativecommons.org/licenses/by/4.0/)
spellingShingle Research Article
Dietel, Eric
Brobeil, Alexander
Tag, Claudia
Gattenloehner, Stefan
Wimmer, Monika
PTPIP51 crosslinks the NFκB signaling and the MAPK pathway in SKBR3 cells
title PTPIP51 crosslinks the NFκB signaling and the MAPK pathway in SKBR3 cells
title_full PTPIP51 crosslinks the NFκB signaling and the MAPK pathway in SKBR3 cells
title_fullStr PTPIP51 crosslinks the NFκB signaling and the MAPK pathway in SKBR3 cells
title_full_unstemmed PTPIP51 crosslinks the NFκB signaling and the MAPK pathway in SKBR3 cells
title_short PTPIP51 crosslinks the NFκB signaling and the MAPK pathway in SKBR3 cells
title_sort ptpip51 crosslinks the nfκb signaling and the mapk pathway in skbr3 cells
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7273389/
https://www.ncbi.nlm.nih.gov/pubmed/32518680
http://dx.doi.org/10.2144/fsoa-2019-0136
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