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Post-mortem diagnosis of intravascular large B-cell lymphoma
Intravascular large B-cell lymphoma (IVLBCL) is a rare (<1%), typically aggressive extranodal variant of mature non-Hodgkin B-cell lymphoma. IVLBCL is characterized by malignant lymphoid cells lodged within blood vessels, particularly capillary channels. Herein, we present a case of a 50-year-old...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7273565/ https://www.ncbi.nlm.nih.gov/pubmed/32485117 http://dx.doi.org/10.1177/0300060520924262 |
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author | Maiese, Aniello La Russa, Raffaele De Matteis, Alessandra Frati, Paola Fineschi, Vittorio |
author_facet | Maiese, Aniello La Russa, Raffaele De Matteis, Alessandra Frati, Paola Fineschi, Vittorio |
author_sort | Maiese, Aniello |
collection | PubMed |
description | Intravascular large B-cell lymphoma (IVLBCL) is a rare (<1%), typically aggressive extranodal variant of mature non-Hodgkin B-cell lymphoma. IVLBCL is characterized by malignant lymphoid cells lodged within blood vessels, particularly capillary channels. Herein, we present a case of a 50-year-old man with a history of myeloradiculitis (∼1 year) and paraparesis requiring hospitalization. During the course of his hospital stay, computed tomography (CT), magnetic resonance imaging, CT-positron emission tomography, and biopsy failed to establish a diagnosis. The patient died 2 months later from bilateral pneumonia. Postmortem examination was undertaken to determine the cause of death. Histologic sections of the patient’s brain, heart, lung, and liver showed aggregates of highly atypical cells bearing enlarged, pleomorphic, and hyperchromatic nuclei. Strong intravascular positivity for CD45 and CD20 markers indicated the cells were of B-cell origin, supporting a diagnosis of IVLBCL. |
format | Online Article Text |
id | pubmed-7273565 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-72735652020-06-15 Post-mortem diagnosis of intravascular large B-cell lymphoma Maiese, Aniello La Russa, Raffaele De Matteis, Alessandra Frati, Paola Fineschi, Vittorio J Int Med Res Case Report Intravascular large B-cell lymphoma (IVLBCL) is a rare (<1%), typically aggressive extranodal variant of mature non-Hodgkin B-cell lymphoma. IVLBCL is characterized by malignant lymphoid cells lodged within blood vessels, particularly capillary channels. Herein, we present a case of a 50-year-old man with a history of myeloradiculitis (∼1 year) and paraparesis requiring hospitalization. During the course of his hospital stay, computed tomography (CT), magnetic resonance imaging, CT-positron emission tomography, and biopsy failed to establish a diagnosis. The patient died 2 months later from bilateral pneumonia. Postmortem examination was undertaken to determine the cause of death. Histologic sections of the patient’s brain, heart, lung, and liver showed aggregates of highly atypical cells bearing enlarged, pleomorphic, and hyperchromatic nuclei. Strong intravascular positivity for CD45 and CD20 markers indicated the cells were of B-cell origin, supporting a diagnosis of IVLBCL. SAGE Publications 2020-06-02 /pmc/articles/PMC7273565/ /pubmed/32485117 http://dx.doi.org/10.1177/0300060520924262 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Case Report Maiese, Aniello La Russa, Raffaele De Matteis, Alessandra Frati, Paola Fineschi, Vittorio Post-mortem diagnosis of intravascular large B-cell lymphoma |
title | Post-mortem diagnosis of intravascular large B-cell lymphoma |
title_full | Post-mortem diagnosis of intravascular large B-cell lymphoma |
title_fullStr | Post-mortem diagnosis of intravascular large B-cell lymphoma |
title_full_unstemmed | Post-mortem diagnosis of intravascular large B-cell lymphoma |
title_short | Post-mortem diagnosis of intravascular large B-cell lymphoma |
title_sort | post-mortem diagnosis of intravascular large b-cell lymphoma |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7273565/ https://www.ncbi.nlm.nih.gov/pubmed/32485117 http://dx.doi.org/10.1177/0300060520924262 |
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