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The association between detection of Mycobacterium avium subsp. paratuberculosis DNA in feces and histopathological classification

Mycobacterium avium subsp. paratuberculosis (MAP) is the causative agent of Johne’s disease (JD), a chronic infectious disease that causes intractable diarrhea in ruminants. To control the occurrence of JD in cattle, a national surveillance is conducted in Japan. Since 2013, real-time quantitative P...

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Detalles Bibliográficos
Autores principales: TANIGUCHI, Yukiko, SAKAKIBARA, Shin-ichi, FUJIHARA, Masatoshi, YAGI, Azusa, FUJIYOSHI, Satoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Veterinary Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7273589/
https://www.ncbi.nlm.nih.gov/pubmed/32161236
http://dx.doi.org/10.1292/jvms.18-0724
Descripción
Sumario:Mycobacterium avium subsp. paratuberculosis (MAP) is the causative agent of Johne’s disease (JD), a chronic infectious disease that causes intractable diarrhea in ruminants. To control the occurrence of JD in cattle, a national surveillance is conducted in Japan. Since 2013, real-time quantitative PCR has been used for definite diagnosis. In this study, we compared the amount of fecal MAP DNA with histopathological classification of ileocecal lesions. Multinomial logistic regression models enabled us to predict the probability of finding the histopathological classification from the amount of fecal MAP DNA. These results suggest that shedding level of MAP DNA could act as an indicator of JD progression.