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A neonate with Langerhans cell histiocytosis presenting as blueberry muffin rash: Case report and review of the literature
In our case report, we discuss a 1-day-old boy presenting with blueberry muffin syndrome diagnosed with Langerhans cell histiocytosis. The diagnosis complicated by an initial difficult-to-interpret biopsy showing only a hint of perifollicular CD1a-positive cells; however, given our team’s strong cli...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7273623/ https://www.ncbi.nlm.nih.gov/pubmed/32547754 http://dx.doi.org/10.1177/2050313X20919616 |
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author | Cyr, Janelle Langley, Annie Demellawy, Dina El Ramien, Michele |
author_facet | Cyr, Janelle Langley, Annie Demellawy, Dina El Ramien, Michele |
author_sort | Cyr, Janelle |
collection | PubMed |
description | In our case report, we discuss a 1-day-old boy presenting with blueberry muffin syndrome diagnosed with Langerhans cell histiocytosis. The diagnosis complicated by an initial difficult-to-interpret biopsy showing only a hint of perifollicular CD1a-positive cells; however, given our team’s strong clinical suspicion of Langerhans cell histiocytosis, a second biopsy of a more mature lesion was done and showed typical histopathology. This case introduces the possibility of perifollicular Langerhans cells early in this condition, demonstrates the importance of appropriate biopsy site selection, and highlights the importance of maintaining a high degree of suspicion when there is poor clinicopathologic correlation. Our case report contains a comprehensive table which reviews the systemic and cutaneous clinical features, as well as the laboratory, pathology, and imaging findings for the differential diagnoses of blueberry muffin baby. |
format | Online Article Text |
id | pubmed-7273623 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-72736232020-06-15 A neonate with Langerhans cell histiocytosis presenting as blueberry muffin rash: Case report and review of the literature Cyr, Janelle Langley, Annie Demellawy, Dina El Ramien, Michele SAGE Open Med Case Rep JCMS Case Report In our case report, we discuss a 1-day-old boy presenting with blueberry muffin syndrome diagnosed with Langerhans cell histiocytosis. The diagnosis complicated by an initial difficult-to-interpret biopsy showing only a hint of perifollicular CD1a-positive cells; however, given our team’s strong clinical suspicion of Langerhans cell histiocytosis, a second biopsy of a more mature lesion was done and showed typical histopathology. This case introduces the possibility of perifollicular Langerhans cells early in this condition, demonstrates the importance of appropriate biopsy site selection, and highlights the importance of maintaining a high degree of suspicion when there is poor clinicopathologic correlation. Our case report contains a comprehensive table which reviews the systemic and cutaneous clinical features, as well as the laboratory, pathology, and imaging findings for the differential diagnoses of blueberry muffin baby. SAGE Publications 2020-05-27 /pmc/articles/PMC7273623/ /pubmed/32547754 http://dx.doi.org/10.1177/2050313X20919616 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | JCMS Case Report Cyr, Janelle Langley, Annie Demellawy, Dina El Ramien, Michele A neonate with Langerhans cell histiocytosis presenting as blueberry muffin rash: Case report and review of the literature |
title | A neonate with Langerhans cell histiocytosis presenting as blueberry
muffin rash: Case report and review of the literature |
title_full | A neonate with Langerhans cell histiocytosis presenting as blueberry
muffin rash: Case report and review of the literature |
title_fullStr | A neonate with Langerhans cell histiocytosis presenting as blueberry
muffin rash: Case report and review of the literature |
title_full_unstemmed | A neonate with Langerhans cell histiocytosis presenting as blueberry
muffin rash: Case report and review of the literature |
title_short | A neonate with Langerhans cell histiocytosis presenting as blueberry
muffin rash: Case report and review of the literature |
title_sort | neonate with langerhans cell histiocytosis presenting as blueberry
muffin rash: case report and review of the literature |
topic | JCMS Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7273623/ https://www.ncbi.nlm.nih.gov/pubmed/32547754 http://dx.doi.org/10.1177/2050313X20919616 |
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