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Cytotoxic Granule Trafficking and Fusion in Synaptotagmin7-Deficient Cytotoxic T Lymphocytes

Granules of cytotoxic T lymphocytes (CTL) are derived from the lysosomal compartment. Synaptotagmin7 (Syt7) appears to be the calcium sensor triggering fusion of lysosomes in fibroblasts. Syt7 has been proposed to control cytotoxic granule (CG) fusion in lymphocytes and mice lacking Syt7 have reduce...

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Detalles Bibliográficos
Autores principales:	Sleiman, Marwa, Stevens, David R., Chitirala, Praneeth, Rettig, Jens
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7273742/ https://www.ncbi.nlm.nih.gov/pubmed/32547563 http://dx.doi.org/10.3389/fimmu.2020.01080

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