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Identification of New Biomarkers of Posturo-Locomotor Instability in a Rodent Model of Vestibular Pathology
The vestibular system plays a crucial role in maintaining postural balance. Unilateral vestibular lesions result in a typical syndrome characterized by postural imbalance, altered locomotor patterns and gaze stabilization, as well as cognitive and neurovegetative disorders. One of the main difficult...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7273747/ https://www.ncbi.nlm.nih.gov/pubmed/32547480 http://dx.doi.org/10.3389/fneur.2020.00470 |
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author | Marouane, Emna Rastoldo, Guillaume El Mahmoudi, Nada Péricat, David Chabbert, Christian Artzner, Vincent Tighilet, Brahim |
author_facet | Marouane, Emna Rastoldo, Guillaume El Mahmoudi, Nada Péricat, David Chabbert, Christian Artzner, Vincent Tighilet, Brahim |
author_sort | Marouane, Emna |
collection | PubMed |
description | The vestibular system plays a crucial role in maintaining postural balance. Unilateral vestibular lesions result in a typical syndrome characterized by postural imbalance, altered locomotor patterns and gaze stabilization, as well as cognitive and neurovegetative disorders. One of the main difficulties encountered in the development of new anti-vertigo drugs is the lack of sensitivity in the evaluation of this syndrome. Qualitative assessments of the vestibular syndrome have been developed, but methods of conducting quantitative evaluations are critically lacking. Recently, assessments with a dynamic weight-bearing device (DWB®, Bioseb) revealed postural alterations in rats subjected to unilateral vestibular neurectomy (UVN). Our team is evaluating a new version of this device capable of quantifying additional parameters of postural and locomotor equilibrium. The objective of this study was to use this device to assess these new posturo-locomotor parameters in a rat model of a vestibular pathology. The biomarkers measured by this device are as follows: the barycenter, the support surface and the weight distribution of the rats when they were moving or stationary. Before UVN, the rats showed a symmetric distribution of their weight along the lateral axis. In the acute phase after UVN on the left side, the rats distributed more weight on the right side than on the left side and then distributed more weight on the left side. These results corroborate those presented in our previous study. The support surface of the rats increased between 1 day and 30 days after UVN, and the barycenter distribution reflected the weight distribution. In addition, our results show smaller changes in the weight distributions when the animals are moving compared with when they are stationary in the acute phase after UVN. This study provides new information on the static and dynamic postural balance patterns observed after unilateral vestibular loss in rats. These data are relevant because they objectively quantify the posturo-locomotor component of vestibular syndrome as well as the compensatory strategies used after vestibular loss. These results may guide the development of rehabilitation protocols for vestibular patients and the validation of pharmacological compounds favoring the restoration of equilibrium. |
format | Online Article Text |
id | pubmed-7273747 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-72737472020-06-15 Identification of New Biomarkers of Posturo-Locomotor Instability in a Rodent Model of Vestibular Pathology Marouane, Emna Rastoldo, Guillaume El Mahmoudi, Nada Péricat, David Chabbert, Christian Artzner, Vincent Tighilet, Brahim Front Neurol Neurology The vestibular system plays a crucial role in maintaining postural balance. Unilateral vestibular lesions result in a typical syndrome characterized by postural imbalance, altered locomotor patterns and gaze stabilization, as well as cognitive and neurovegetative disorders. One of the main difficulties encountered in the development of new anti-vertigo drugs is the lack of sensitivity in the evaluation of this syndrome. Qualitative assessments of the vestibular syndrome have been developed, but methods of conducting quantitative evaluations are critically lacking. Recently, assessments with a dynamic weight-bearing device (DWB®, Bioseb) revealed postural alterations in rats subjected to unilateral vestibular neurectomy (UVN). Our team is evaluating a new version of this device capable of quantifying additional parameters of postural and locomotor equilibrium. The objective of this study was to use this device to assess these new posturo-locomotor parameters in a rat model of a vestibular pathology. The biomarkers measured by this device are as follows: the barycenter, the support surface and the weight distribution of the rats when they were moving or stationary. Before UVN, the rats showed a symmetric distribution of their weight along the lateral axis. In the acute phase after UVN on the left side, the rats distributed more weight on the right side than on the left side and then distributed more weight on the left side. These results corroborate those presented in our previous study. The support surface of the rats increased between 1 day and 30 days after UVN, and the barycenter distribution reflected the weight distribution. In addition, our results show smaller changes in the weight distributions when the animals are moving compared with when they are stationary in the acute phase after UVN. This study provides new information on the static and dynamic postural balance patterns observed after unilateral vestibular loss in rats. These data are relevant because they objectively quantify the posturo-locomotor component of vestibular syndrome as well as the compensatory strategies used after vestibular loss. These results may guide the development of rehabilitation protocols for vestibular patients and the validation of pharmacological compounds favoring the restoration of equilibrium. Frontiers Media S.A. 2020-05-29 /pmc/articles/PMC7273747/ /pubmed/32547480 http://dx.doi.org/10.3389/fneur.2020.00470 Text en Copyright © 2020 Marouane, Rastoldo, El Mahmoudi, Péricat, Chabbert, Artzner and Tighilet. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neurology Marouane, Emna Rastoldo, Guillaume El Mahmoudi, Nada Péricat, David Chabbert, Christian Artzner, Vincent Tighilet, Brahim Identification of New Biomarkers of Posturo-Locomotor Instability in a Rodent Model of Vestibular Pathology |
title | Identification of New Biomarkers of Posturo-Locomotor Instability in a Rodent Model of Vestibular Pathology |
title_full | Identification of New Biomarkers of Posturo-Locomotor Instability in a Rodent Model of Vestibular Pathology |
title_fullStr | Identification of New Biomarkers of Posturo-Locomotor Instability in a Rodent Model of Vestibular Pathology |
title_full_unstemmed | Identification of New Biomarkers of Posturo-Locomotor Instability in a Rodent Model of Vestibular Pathology |
title_short | Identification of New Biomarkers of Posturo-Locomotor Instability in a Rodent Model of Vestibular Pathology |
title_sort | identification of new biomarkers of posturo-locomotor instability in a rodent model of vestibular pathology |
topic | Neurology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7273747/ https://www.ncbi.nlm.nih.gov/pubmed/32547480 http://dx.doi.org/10.3389/fneur.2020.00470 |
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