Cargando…

Rhein Derivative 4F Inhibits the Malignant Phenotype of Breast Cancer by Downregulating Rac1 Protein

BACKGROUND: Triple-negative breast cancer is a common malignant tumor with unfavorable prognosis affecting women worldwide; thus, there is an urgent need for novel therapeutic drugs with improved anti-tumor activity. Rac family small GTPase 1 (Rac1) plays an important role in malignant behavior and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Xinxiao, Liu, Yunfeng, Zhao, Yuhua, Tian, Wei, Zhai, Lina, Pang, Huifeng, Kang, Jiankang, Hou, Huaxin, Chen, Yanhua, Li, Danrong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7274043/ https://www.ncbi.nlm.nih.gov/pubmed/32547389 http://dx.doi.org/10.3389/fphar.2020.00754

Ejemplares similares

Rhein for treating diabetes mellitus: A pharmacological and mechanistic overview
por: Deng, Tingting, et al.
Publicado: (2023)

Pharmacokinetics and Pharmacodynamics of the Combination of Rhein and Curcumin in the Treatment of Chronic Kidney Disease in Rats
por: He, Xiaoying, et al.
Publicado: (2020)

A Comprehensive and System Review for the Pharmacological Mechanism of Action of Rhein, an Active Anthraquinone Ingredient
por: Sun, Hao, et al.
Publicado: (2016)

A Significant Association Between Rhein and Diabetic Nephropathy in Animals: A Systematic Review and Meta-Analysis
por: Hu, Heng-Chang, et al.
Publicado: (2019)

Rhein Protects Against Neurological Deficits After Traumatic Brain Injury in Mice via Inhibiting Neuronal Pyroptosis
por: Bi, Fangfang, et al.
Publicado: (2020)

Rhein Protects Against Severe Acute Pancreatitis In vitro and In vivo by Regulating the JAK2/STAT3 Pathway
por: Yang, Xiaofang, et al.
Publicado: (2022)

Rhein ameliorates transverse aortic constriction-induced cardiac hypertrophy via regulating STAT3 and p38 MAPK signaling pathways
por: Li, Run-Jing, et al.
Publicado: (2022)

Synergy of Taxol and rhein lysinate associated with the downregulation of ERK activation in lung carcinoma cells
por: ZHEN, YONG-ZHAN, et al.
Publicado: (2013)

Functional Metabolomics Analysis Elucidating the Metabolic Biomarker and Key Pathway Change Associated With the Chronic Glomerulonephritis and Revealing Action Mechanism of Rhein
por: Yu, Wei, et al.
Publicado: (2020)

Ropivacaine Inhibits Lung Cancer Cell Malignancy Through Downregulation of Cellular Signaling Including HIF-1α In Vitro
por: Shen, Junmei, et al.
Publicado: (2022)

Rhein inhibits malignant phenotypes of human renal cell carcinoma by impacting on MAPK/NF-κB signaling pathways
por: Ma, Ya-Li, et al.
Publicado: (2018)

Rhein Meeting Program
por: The HiLumi LHC Collaboration
Publicado: (2014)

Rhein Relieves Oxidative Stress in an Aβ(1-42) Oligomer-Burdened Neuron Model by Activating the SIRT1/PGC-1α-Regulated Mitochondrial Biogenesis
por: Yin, Zhihui, et al.
Publicado: (2021)

Rhein Suppresses Lung Inflammatory Injury Induced by Human Respiratory Syncytial Virus Through Inhibiting NLRP3 Inflammasome Activation via NF-κB Pathway in Mice
por: Shen, Cunsi, et al.
Publicado: (2020)

Tetramethylpyrazine ameliorates acute lung injury by regulating the Rac1/LIMK1 signaling pathway
por: Min, Simin, et al.
Publicado: (2023)

Update on Pharmacological Activities, Security, and Pharmacokinetics of Rhein
por: Li, Gang-Min, et al.
Publicado: (2021)

Rhein: A Review of Pharmacological Activities
por: Zhou, Yan-Xi, et al.
Publicado: (2015)

The Molecular Mechanism of Rhein in Diabetic Nephropathy
por: Zeng, Cong-Cong, et al.
Publicado: (2014)

Dr. Meyer L. Rhein’s Technique
por: Southwell, Charles
Publicado: (1904)

A Reply to Dr. Rhein’s Answer
por: Wedelstaedt, E. K.
Publicado: (1904)

Effects of Rhein on Bile Acid Homeostasis in Rats
por: Xian, Zhong, et al.
Publicado: (2020)

Inhibition of Rac1 reverses enzalutamide resistance in castration-resistant prostate cancer
por: Chen, Xiaoliang, et al.
Publicado: (2020)

6th Rhein Workshop on Computer Algebra
por: Calmet, J
Publicado: (1998)

Prediction of Aortic Stenosis Progression by (18)F-FDG and (18)F-NaF PET/CT in Different Aortic Valve Phenotypes
por: Murtazalieva, Patimat, et al.
Publicado: (2022)

Inhibition of Female and Male Human Detrusor Smooth Muscle Contraction by the Rac Inhibitors EHT1864 and NSC23766
por: Li, Bingsheng, et al.
Publicado: (2020)

Rac GTPases in Hematological Malignancies
por: Durand-Onaylı, Valerie, et al.
Publicado: (2018)

Safety and Efficacy of Bromodomain and Extra-Terminal Inhibitors for the Treatment of Hematological Malignancies and Solid Tumors: A Systematic Study of Clinical Trials
por: Sun, Yanli, et al.
Publicado: (2021)

Downregulation of MCM8 expression restrains the malignant progression of cholangiocarcinoma
por: Hao, Jingcheng, et al.
Publicado: (2021)

Dual Tumor Suppressor and Tumor Promoter Action of Sirtuins in Determining Malignant Phenotype
por: Carafa, Vincenzo, et al.
Publicado: (2019)

Rhein Induces Apoptosis in Human Breast Cancer Cells
por: Chang, Ching-Yao, et al.
Publicado: (2012)

A Modified Method for Isolation of Rhein from Senna
por: Mehta, Namita, et al.
Publicado: (2009)

Dynamic influence of Rhein lysinate on HeLa cells
por: Liu, Jiang, et al.
Publicado: (2018)

Chinese Dragon’s Blood EtOAc Extract Inhibits Liver Cancer Growth Through Downregulation of Smad3
por: Chen, Xiaonan, et al.
Publicado: (2020)

Rhein Induces a Necrosis-Apoptosis Switch in Pancreatic Acinar Cells
por: Zhao, Xianlin, et al.
Publicado: (2014)

Rhein laden pH-responsive polymeric nanoparticles for treatment of osteoarthritis
por: Hu, Bo, et al.
Publicado: (2020)

Downregulated MicroRNA-327 Attenuates Oxidative Stress–Mediated Myocardial Ischemia Reperfusion Injury Through Regulating the FGF10/Akt/Nrf2 Signaling Pathway
por: Zheng, Tao, et al.
Publicado: (2021)

Insights Into the Resistance Mechanisms of Inhibitors to FLT3 F691L Mutation via an Integrated Computational Approach
por: Sun, Yunfeng, et al.
Publicado: (2019)

NEDD9 Facilitates Hypoxia-Induced Gastric Cancer Cell Migration via MICAL1 Related Rac1 Activation
por: Zhao, Shuo, et al.
Publicado: (2019)

Predicting new molecular targets for rhein using network pharmacology
por: Zhang, Aihua, et al.
Publicado: (2012)

Gut Microbiota Play an Essential Role in the Antidiabetic Effects of Rhein
por: Wang, Ruifeng, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_c6j5o84n9vta3h1vnenr6rvvc1