Mechanisms involved in the development of thrombocytopenia in patients with COVID-19

Corona Virus Disease 2019 (COVID-19) is caused by the novel coronavirus SARS-CoV-2. Emerging genetic and clinical evidence suggests similarities between COVID-19 patients and those with severe acute respiratory syndrome and Middle East respiratory syndrome. Hematological changes such as lymphopenia...

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Autores principales: Zhang, Yujiao, Zeng, Xiaoyuan, Jiao, Yingying, Li, Zongpeng, Liu, Qifa, Ye, Jieyu, Yang, Mo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Ltd. 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7274097/
https://www.ncbi.nlm.nih.gov/pubmed/32535232
http://dx.doi.org/10.1016/j.thromres.2020.06.008
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author Zhang, Yujiao
Zeng, Xiaoyuan
Jiao, Yingying
Li, Zongpeng
Liu, Qifa
Ye, Jieyu
Yang, Mo
author_facet Zhang, Yujiao
Zeng, Xiaoyuan
Jiao, Yingying
Li, Zongpeng
Liu, Qifa
Ye, Jieyu
Yang, Mo
author_sort Zhang, Yujiao
collection PubMed
description Corona Virus Disease 2019 (COVID-19) is caused by the novel coronavirus SARS-CoV-2. Emerging genetic and clinical evidence suggests similarities between COVID-19 patients and those with severe acute respiratory syndrome and Middle East respiratory syndrome. Hematological changes such as lymphopenia and thrombocytopenia are not rare in COVID-19 patients, and a smaller population of these patients had leukopenia. Thrombocytopenia was detected in 5–41.7% of the patients with COVID-19. Analyzing the dynamic decrease in platelet counts may be useful in the prognosis of patients with COVID-19. However, the mechanisms underlying the development of thrombocytopenia remain to be elucidated. This review summarizes the hematological changes in patients infected with SARS-CoV-2 and possible underlying mechanisms of thrombocytopenia development.
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spelling pubmed-72740972020-06-05 Mechanisms involved in the development of thrombocytopenia in patients with COVID-19 Zhang, Yujiao Zeng, Xiaoyuan Jiao, Yingying Li, Zongpeng Liu, Qifa Ye, Jieyu Yang, Mo Thromb Res Article Corona Virus Disease 2019 (COVID-19) is caused by the novel coronavirus SARS-CoV-2. Emerging genetic and clinical evidence suggests similarities between COVID-19 patients and those with severe acute respiratory syndrome and Middle East respiratory syndrome. Hematological changes such as lymphopenia and thrombocytopenia are not rare in COVID-19 patients, and a smaller population of these patients had leukopenia. Thrombocytopenia was detected in 5–41.7% of the patients with COVID-19. Analyzing the dynamic decrease in platelet counts may be useful in the prognosis of patients with COVID-19. However, the mechanisms underlying the development of thrombocytopenia remain to be elucidated. This review summarizes the hematological changes in patients infected with SARS-CoV-2 and possible underlying mechanisms of thrombocytopenia development. Published by Elsevier Ltd. 2020-09 2020-06-05 /pmc/articles/PMC7274097/ /pubmed/32535232 http://dx.doi.org/10.1016/j.thromres.2020.06.008 Text en © 2020 Published by Elsevier Ltd. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Zhang, Yujiao
Zeng, Xiaoyuan
Jiao, Yingying
Li, Zongpeng
Liu, Qifa
Ye, Jieyu
Yang, Mo
Mechanisms involved in the development of thrombocytopenia in patients with COVID-19
title Mechanisms involved in the development of thrombocytopenia in patients with COVID-19
title_full Mechanisms involved in the development of thrombocytopenia in patients with COVID-19
title_fullStr Mechanisms involved in the development of thrombocytopenia in patients with COVID-19
title_full_unstemmed Mechanisms involved in the development of thrombocytopenia in patients with COVID-19
title_short Mechanisms involved in the development of thrombocytopenia in patients with COVID-19
title_sort mechanisms involved in the development of thrombocytopenia in patients with covid-19
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7274097/
https://www.ncbi.nlm.nih.gov/pubmed/32535232
http://dx.doi.org/10.1016/j.thromres.2020.06.008
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