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How to reduce epidemic peaks keeping under control the time-span of the epidemic

One of the main challenges of the measures against the COVID-19 epidemic is to reduce the amplitude of the epidemic peak without increasing without control its timescale. We investigate this problem using the SIR model for the epidemic dynamics, for which reduction of the epidemic peak I(P) can be a...

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Autor principal: Cadoni, Mariano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7274126/
https://www.ncbi.nlm.nih.gov/pubmed/32518474
http://dx.doi.org/10.1016/j.chaos.2020.109940
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author Cadoni, Mariano
author_facet Cadoni, Mariano
author_sort Cadoni, Mariano
collection PubMed
description One of the main challenges of the measures against the COVID-19 epidemic is to reduce the amplitude of the epidemic peak without increasing without control its timescale. We investigate this problem using the SIR model for the epidemic dynamics, for which reduction of the epidemic peak I(P) can be achieved only at the price of increasing the time t(P) of its occurrence and its entire time-span t(E). By means of a time reparametrization we linearize the equations for the SIR dynamics. This allows us to solve exactly the dynamics in the time domain and to derive the scaling behaviour of the size, the timescale and the speed of the epidemics, by reducing the infection rate α and by increasing the removal rate β by a factor of λ. We show that for a given value of the size (I(P), the total, I(E) and average [Formula: see text] number of infected), its occurrence time t(P) and entire time-span t(E) can be reduced by a factor 1/λ if the reduction of I is achieved by increasing the removal rate instead of reducing the infection rate. Thus, epidemic containment measures based on tracing, early detection followed by prompt isolation of infected individuals are more efficient than those based on social distancing. We apply our results to the COVID-19 epidemic in Northern Italy. We show that the peak time t(P) and the entire time span t(E) could have been reduced by a factor 0.9 ≤ 1/λ ≤ 0.34 with containment measures focused on increasing β instead of reducing α.
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spelling pubmed-72741262020-06-05 How to reduce epidemic peaks keeping under control the time-span of the epidemic Cadoni, Mariano Chaos Solitons Fractals Article One of the main challenges of the measures against the COVID-19 epidemic is to reduce the amplitude of the epidemic peak without increasing without control its timescale. We investigate this problem using the SIR model for the epidemic dynamics, for which reduction of the epidemic peak I(P) can be achieved only at the price of increasing the time t(P) of its occurrence and its entire time-span t(E). By means of a time reparametrization we linearize the equations for the SIR dynamics. This allows us to solve exactly the dynamics in the time domain and to derive the scaling behaviour of the size, the timescale and the speed of the epidemics, by reducing the infection rate α and by increasing the removal rate β by a factor of λ. We show that for a given value of the size (I(P), the total, I(E) and average [Formula: see text] number of infected), its occurrence time t(P) and entire time-span t(E) can be reduced by a factor 1/λ if the reduction of I is achieved by increasing the removal rate instead of reducing the infection rate. Thus, epidemic containment measures based on tracing, early detection followed by prompt isolation of infected individuals are more efficient than those based on social distancing. We apply our results to the COVID-19 epidemic in Northern Italy. We show that the peak time t(P) and the entire time span t(E) could have been reduced by a factor 0.9 ≤ 1/λ ≤ 0.34 with containment measures focused on increasing β instead of reducing α. Elsevier Ltd. 2020-09 2020-06-05 /pmc/articles/PMC7274126/ /pubmed/32518474 http://dx.doi.org/10.1016/j.chaos.2020.109940 Text en © 2020 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Cadoni, Mariano
How to reduce epidemic peaks keeping under control the time-span of the epidemic
title How to reduce epidemic peaks keeping under control the time-span of the epidemic
title_full How to reduce epidemic peaks keeping under control the time-span of the epidemic
title_fullStr How to reduce epidemic peaks keeping under control the time-span of the epidemic
title_full_unstemmed How to reduce epidemic peaks keeping under control the time-span of the epidemic
title_short How to reduce epidemic peaks keeping under control the time-span of the epidemic
title_sort how to reduce epidemic peaks keeping under control the time-span of the epidemic
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7274126/
https://www.ncbi.nlm.nih.gov/pubmed/32518474
http://dx.doi.org/10.1016/j.chaos.2020.109940
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