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RNF8 Dysregulation and Down-regulation During HTLV-1 Infection Promote Genomic Instability in Adult T-Cell Leukemia

The genomic instability associated with adult T cell leukemia/lymphoma (ATL) is causally linked to Tax, the HTLV-1 viral oncoprotein, but the underlying mechanism is not fully understood. We have previously shown that Tax hijacks and aberrantly activates ring finger protein 8 (RNF8) — a lysine 63 (K...

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Detalles Bibliográficos
Autores principales:	Zhi, Huijun, Guo, Xin, Ho, Yik-Khuan, Pasupala, Nagesh, Engstrom, Hampus Alexander Anders, Semmes, Oliver John, Giam, Chou-Zen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7274470/ https://www.ncbi.nlm.nih.gov/pubmed/32453758 http://dx.doi.org/10.1371/journal.ppat.1008618

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