Fibroblast growth factors signaling in bone metastasis

Many solid tumors metastasize to bone, but only prostate cancer has bone as a single, dominant metastatic site. Recently, the FGF axis has been implicated in cancer progression in some tumors and mounting evidence indicate that it mediates prostate cancer bone metastases. The FGF axis has an importa...

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Detalles Bibliográficos
Autores principales: Labanca, Estefania, Vazquez, Elba S, Corn, Paul G, Roberts, Justin M, Wang, Fen, Logothetis, Christopher J, Navone, Nora M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bioscientifica Ltd 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7274538/
https://www.ncbi.nlm.nih.gov/pubmed/32369771
http://dx.doi.org/10.1530/ERC-19-0472
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author Labanca, Estefania
Vazquez, Elba S
Corn, Paul G
Roberts, Justin M
Wang, Fen
Logothetis, Christopher J
Navone, Nora M
author_facet Labanca, Estefania
Vazquez, Elba S
Corn, Paul G
Roberts, Justin M
Wang, Fen
Logothetis, Christopher J
Navone, Nora M
author_sort Labanca, Estefania
collection PubMed
description Many solid tumors metastasize to bone, but only prostate cancer has bone as a single, dominant metastatic site. Recently, the FGF axis has been implicated in cancer progression in some tumors and mounting evidence indicate that it mediates prostate cancer bone metastases. The FGF axis has an important role in bone biology and mediates cell-to-cell communication. Therefore, we discuss here basic concepts of bone biology, FGF signaling axis, and FGF axis function in adult bone, to integrate these concepts in our current understanding of the role of FGF axis in bone metastases.
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spelling pubmed-72745382020-06-10 Fibroblast growth factors signaling in bone metastasis Labanca, Estefania Vazquez, Elba S Corn, Paul G Roberts, Justin M Wang, Fen Logothetis, Christopher J Navone, Nora M Endocr Relat Cancer Review Many solid tumors metastasize to bone, but only prostate cancer has bone as a single, dominant metastatic site. Recently, the FGF axis has been implicated in cancer progression in some tumors and mounting evidence indicate that it mediates prostate cancer bone metastases. The FGF axis has an important role in bone biology and mediates cell-to-cell communication. Therefore, we discuss here basic concepts of bone biology, FGF signaling axis, and FGF axis function in adult bone, to integrate these concepts in our current understanding of the role of FGF axis in bone metastases. Bioscientifica Ltd 2020-05-04 /pmc/articles/PMC7274538/ /pubmed/32369771 http://dx.doi.org/10.1530/ERC-19-0472 Text en © 2020 The authors http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Labanca, Estefania
Vazquez, Elba S
Corn, Paul G
Roberts, Justin M
Wang, Fen
Logothetis, Christopher J
Navone, Nora M
Fibroblast growth factors signaling in bone metastasis
title Fibroblast growth factors signaling in bone metastasis
title_full Fibroblast growth factors signaling in bone metastasis
title_fullStr Fibroblast growth factors signaling in bone metastasis
title_full_unstemmed Fibroblast growth factors signaling in bone metastasis
title_short Fibroblast growth factors signaling in bone metastasis
title_sort fibroblast growth factors signaling in bone metastasis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7274538/
https://www.ncbi.nlm.nih.gov/pubmed/32369771
http://dx.doi.org/10.1530/ERC-19-0472
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