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Divergent Cl(-) and H(+) pathways underlie transport coupling and gating in CLC exchangers and channels
The CLC family comprises H(+)-coupled exchangers and Cl(-) channels, and mutations causing their dysfunction lead to genetic disorders. The CLC exchangers, unlike canonical 'ping-pong' antiporters, simultaneously bind and translocate substrates through partially congruent pathways. How ion...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
eLife Sciences Publications, Ltd
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7274781/ https://www.ncbi.nlm.nih.gov/pubmed/32343228 http://dx.doi.org/10.7554/eLife.51224 |