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Differences in reward biased spatial representations in the lateral septum and hippocampus

The lateral septum (LS), which is innervated by the hippocampus, is known to represent spatial information. However, the details of place representation in the LS, and whether this place information is combined with reward signaling, remains unknown. We simultaneously recorded from rat CA1 and caudo...

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Autores principales: Wirtshafter, Hannah S, Wilson, Matthew A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7274787/
https://www.ncbi.nlm.nih.gov/pubmed/32452763
http://dx.doi.org/10.7554/eLife.55252
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author Wirtshafter, Hannah S
Wilson, Matthew A
author_facet Wirtshafter, Hannah S
Wilson, Matthew A
author_sort Wirtshafter, Hannah S
collection PubMed
description The lateral septum (LS), which is innervated by the hippocampus, is known to represent spatial information. However, the details of place representation in the LS, and whether this place information is combined with reward signaling, remains unknown. We simultaneously recorded from rat CA1 and caudodorsal lateral septum in rat during a rewarded navigation task and compared spatial firing in the two areas. While LS place cells are less numerous than in hippocampus, they are similar to the hippocampus in field size and number of fields per cell, but with field shape and center distributions that are more skewed toward reward. Spike cross-correlations between the hippocampus and LS are greatest for cells that have reward-proximate place fields, suggesting a role for the LS in relaying task-relevant hippocampal spatial information to downstream areas, such as the VTA.
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spelling pubmed-72747872020-06-09 Differences in reward biased spatial representations in the lateral septum and hippocampus Wirtshafter, Hannah S Wilson, Matthew A eLife Neuroscience The lateral septum (LS), which is innervated by the hippocampus, is known to represent spatial information. However, the details of place representation in the LS, and whether this place information is combined with reward signaling, remains unknown. We simultaneously recorded from rat CA1 and caudodorsal lateral septum in rat during a rewarded navigation task and compared spatial firing in the two areas. While LS place cells are less numerous than in hippocampus, they are similar to the hippocampus in field size and number of fields per cell, but with field shape and center distributions that are more skewed toward reward. Spike cross-correlations between the hippocampus and LS are greatest for cells that have reward-proximate place fields, suggesting a role for the LS in relaying task-relevant hippocampal spatial information to downstream areas, such as the VTA. eLife Sciences Publications, Ltd 2020-05-26 /pmc/articles/PMC7274787/ /pubmed/32452763 http://dx.doi.org/10.7554/eLife.55252 Text en © 2020, Wirtshafter and Wilson http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Wirtshafter, Hannah S
Wilson, Matthew A
Differences in reward biased spatial representations in the lateral septum and hippocampus
title Differences in reward biased spatial representations in the lateral septum and hippocampus
title_full Differences in reward biased spatial representations in the lateral septum and hippocampus
title_fullStr Differences in reward biased spatial representations in the lateral septum and hippocampus
title_full_unstemmed Differences in reward biased spatial representations in the lateral septum and hippocampus
title_short Differences in reward biased spatial representations in the lateral septum and hippocampus
title_sort differences in reward biased spatial representations in the lateral septum and hippocampus
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7274787/
https://www.ncbi.nlm.nih.gov/pubmed/32452763
http://dx.doi.org/10.7554/eLife.55252
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