Cargando…

Cryo-EM structure of NPF-bound human Arp2/3 complex and activation mechanism

Actin-related protein (Arp) 2/3 complex nucleates branched actin networks that drive cell motility. It consists of seven proteins, including two actin-related subunits (Arp2 and Arp3). Two nucleation-promoting factors (NPFs) bind Arp2/3 complex during activation, but the order, specific interactions...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zimmet, Austin, Van Eeuwen, Trevor, Boczkowska, Malgorzata, Rebowski, Grzegorz, Murakami, Kenji, Dominguez, Roberto
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2020
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7274804/ https://www.ncbi.nlm.nih.gov/pubmed/32917641 http://dx.doi.org/10.1126/sciadv.aaz7651

Ejemplares similares

Molecular mechanism of Arp2/3 complex inhibition by Arpin
por: Fregoso, Fred E., et al.
Publicado: (2022)

Mechanism of synergistic activation of Arp2/3 complex by cortactin and WASP-family proteins
por: Fregoso, Fred E., et al.
Publicado: (2023)

PICK1 is implicated in organelle motility in an Arp2/3 complex–independent manner
por: Madasu, Yadaiah, et al.
Publicado: (2015)

The accuracy of protein models automatically built into cryo-EM maps with ARP/wARP
por: Chojnowski, Grzegorz, et al.
Publicado: (2021)

Cryo-EM structures of engineered active bc(1)-cbb(3) type CIII(2)CIV super-complexes and electronic communication between the complexes
por: Steimle, Stefan, et al.
Publicado: (2021)

How Leiomodin and Tropomodulin use a common fold for different actin assembly functions
por: Boczkowska, Malgorzata, et al.
Publicado: (2015)

Cryo-EM structure of TFIIH/Rad4–Rad23–Rad33 in damaged DNA opening in nucleotide excision repair
por: van Eeuwen, Trevor, et al.
Publicado: (2021)

Cryo-EM structure of the Spo11 core complex bound to DNA
por: Yu, You, et al.
Publicado: (2023)

Mechanism of actin N-terminal acetylation
por: Rebowski, Grzegorz, et al.
Publicado: (2020)

Cryo-EM structure of the human MLL1 core complex bound to the nucleosome
por: Park, Sang Ho, et al.
Publicado: (2019)

Cryo-EM Structure of the Fork Protection Complex Bound to CMG at a Replication Fork
por: Baretić, Domagoj, et al.
Publicado: (2020)

Novel cryo-EM structure of an ADP-bound GroEL–GroES complex
por: Kudryavtseva, Sofia S., et al.
Publicado: (2021)

Cryo-EM structure and function of S. pombe complex IV with bound respiratory supercomplex factor
por: Moe, Agnes, et al.
Publicado: (2023)

Cryo-EM of human Arp2/3 complexes provides structural insights into actin nucleation modulation by ARPC5 isoforms
por: von Loeffelholz, Ottilie, et al.
Publicado: (2020)

Cryo-EM structure of substrate-bound human telomerase holoenzyme
por: Nguyen, Thi Hoang Duong, et al.
Publicado: (2018)

Cryo-EM structure of VASH1-SVBP bound to microtubules
por: Li, Faxiang, et al.
Publicado: (2020)

Mechanism of actin filament nucleation by Vibrio VopL and implications for tandem-W domain nucleation
por: Namgoong, Suk, et al.
Publicado: (2011)

Mechanism of actin filament branch formation by Arp2/3 complex revealed by a high-resolution cryo-EM structureof the branch junction
por: Chou, Steven Z., et al.
Publicado: (2022)

A solution to the long-standing problem of actin expression and purification
por: Ceron, Rachel H., et al.
Publicado: (2022)

Publisher Correction: Cryo-EM structure of the human MLL1 core complex bound to the nucleosome
por: Park, Sang Ho, et al.
Publicado: (2020)

Cryo-EM structure of the agonist-bound Hsp90-XAP2-AHR cytosolic complex
por: Gruszczyk, Jakub, et al.
Publicado: (2022)

A cryo-EM structure of KTF1-bound polymerase V transcription elongation complex
por: Zhang, Hong-Wei, et al.
Publicado: (2023)

Cryo-EM Structure of the Exocyst Complex
por: Mei, Kunrong, et al.
Publicado: (2018)

Cryo-EM structure of the SEA complex
por: Tafur, Lucas, et al.
Publicado: (2022)

Cryo-EM structures of the eukaryotic replicative helicase bound to a translocation substrate
por: Abid Ali, Ferdos, et al.
Publicado: (2016)

Cryo-EM structure of a Ca(2+)-bound photosynthetic LH1-RC complex containing multiple αβ-polypeptides
por: Tani, Kazutoshi, et al.
Publicado: (2020)

Cryo-EM structures of the translocational binary toxin complex CDTa-bound CDTb-pore from Clostridioides difficile
por: Kawamoto, Akihiro, et al.
Publicado: (2022)

The cryo-EM resolution revolution and transcription complexes
por: Hanske, Jonas, et al.
Publicado: (2018)

Cryo-EM structure of the prothrombin-prothrombinase complex
por: Ruben, Eliza A., et al.
Publicado: (2022)

Cryo-EM structures of a human ABCG2 mutant trapped in ATP-bound and substrate-bound states
por: Manolaridis, Ioannis, et al.
Publicado: (2018)

Cryo-EM structure of the Ustilago maydis kinesin-5 motor domain bound to microtubules
por: von Loeffelholz, Ottilie, et al.
Publicado: (2019)

Cryo-EM structure of human Pol κ bound to DNA and mono-ubiquitylated PCNA
por: Lancey, Claudia, et al.
Publicado: (2021)

Substrate recognition and cryo-EM structure of the ribosome-bound TAC toxin of Mycobacterium tuberculosis
por: Mansour, Moise, et al.
Publicado: (2022)

Cryo-EM structure of a microtubule-bound parasite kinesin motor and implications for its mechanism and inhibition
por: Cook, Alexander D., et al.
Publicado: (2021)

X-ray and cryo-EM structures of inhibitor-bound cytochrome bc (1) complexes for structure-based drug discovery
por: Amporndanai, Kangsa, et al.
Publicado: (2018)

Cryo-EM structure of the human chemerin receptor 1–Gi protein complex bound to the C-terminal nonapeptide of chemerin
por: Wang, Junlin, et al.
Publicado: (2023)

Cryo-EM structure of human κ-opioid receptor-G(i) complex bound to an endogenous agonist dynorphin A
por: Chen, Yuxiang, et al.
Publicado: (2022)

Cryo EM structure of the rabies virus ribonucleoprotein complex
por: Riedel, Christiane, et al.
Publicado: (2019)

Cryo-EM structure of respiratory complex I at work
por: Parey, Kristian, et al.
Publicado: (2018)

Cryo-EM Studies of Virus-Antibody Immune Complexes
por: Li, Na, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_erhi9nsmre1q68p08ped1iv24b