The methylation status of the embryonic limb skeletal progenitors determines their cell fate in chicken

Digits shape is sculpted by interdigital programmed cell death during limb development. Here, we show that DNA breakage in the periphery of 5-methylcytosine nuclei foci of interdigital precursors precedes cell death. These cells showed higher genome instability than the digit-forming precursors when...

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Detalles Bibliográficos
Autores principales: Sanchez-Fernandez, Cristina, Lorda-Diez, Carlos Ignacio, Hurlé, Juan M., Montero, Juan Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275052/
https://www.ncbi.nlm.nih.gov/pubmed/32504030
http://dx.doi.org/10.1038/s42003-020-1012-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275052/
https://www.ncbi.nlm.nih.gov/pubmed/32504030
http://dx.doi.org/10.1038/s42003-020-1012-3

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