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Ubiquitin transfer by a RING E3 ligase occurs from a closed E2~ubiquitin conformation
Based on extensive structural analysis it was proposed that RING E3 ligases prime the E2~ubiquitin conjugate (E2~Ub) for catalysis by locking it into a closed conformation, where ubiquitin is folded back onto the E2 exposing the restrained thioester bond to attack by substrate nucleophile. However t...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275055/ https://www.ncbi.nlm.nih.gov/pubmed/32503993 http://dx.doi.org/10.1038/s41467-020-16666-y |