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Long noncoding RNA SNHG6 mainly functions as a competing endogenous RNA in human tumors

Increased expression of the small nucleolar RNA host gene 6 (SNHG6) has been reported in different cancers, such as hepatocellular carcinoma, colorectal cancer, and lung cancer. The high expression level of SNHG6 is associated with tumor progression and poor prognosis. This paper provides an overvie...

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Autores principales: Wang, Hui-shan, Zhang, Wen, Zhu, Han-long, Li, Quan-peng, Miao, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275348/
https://www.ncbi.nlm.nih.gov/pubmed/32518528
http://dx.doi.org/10.1186/s12935-020-01303-x
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author Wang, Hui-shan
Zhang, Wen
Zhu, Han-long
Li, Quan-peng
Miao, Lin
author_facet Wang, Hui-shan
Zhang, Wen
Zhu, Han-long
Li, Quan-peng
Miao, Lin
author_sort Wang, Hui-shan
collection PubMed
description Increased expression of the small nucleolar RNA host gene 6 (SNHG6) has been reported in different cancers, such as hepatocellular carcinoma, colorectal cancer, and lung cancer. The high expression level of SNHG6 is associated with tumor progression and poor prognosis. This paper provides an overview of recent studies on the oncogenic role and potential clinical utilities of SNHG6. Upregulated SNHG6 arrests tumor cell cycle and reduces apoptosis but promotes migration, invasion, metastasis, epithelial-mesenchymal transition (EMT), and chemoresistance in tumors. Mechanically, SNHG6 primarily sponges tumor suppressor microRNA (miRNA), functioning as a competing endogenous RNA. Once sponged, miRNA is unable to degrade, silence, or hamper the translation of its downstream, mostly oncogenic genes, ultimately driving cancer-related processes. Thus, SNHG6 might serve as a biomarker for cancer diagnosis and prognosis.
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spelling pubmed-72753482020-06-08 Long noncoding RNA SNHG6 mainly functions as a competing endogenous RNA in human tumors Wang, Hui-shan Zhang, Wen Zhu, Han-long Li, Quan-peng Miao, Lin Cancer Cell Int Review Increased expression of the small nucleolar RNA host gene 6 (SNHG6) has been reported in different cancers, such as hepatocellular carcinoma, colorectal cancer, and lung cancer. The high expression level of SNHG6 is associated with tumor progression and poor prognosis. This paper provides an overview of recent studies on the oncogenic role and potential clinical utilities of SNHG6. Upregulated SNHG6 arrests tumor cell cycle and reduces apoptosis but promotes migration, invasion, metastasis, epithelial-mesenchymal transition (EMT), and chemoresistance in tumors. Mechanically, SNHG6 primarily sponges tumor suppressor microRNA (miRNA), functioning as a competing endogenous RNA. Once sponged, miRNA is unable to degrade, silence, or hamper the translation of its downstream, mostly oncogenic genes, ultimately driving cancer-related processes. Thus, SNHG6 might serve as a biomarker for cancer diagnosis and prognosis. BioMed Central 2020-06-06 /pmc/articles/PMC7275348/ /pubmed/32518528 http://dx.doi.org/10.1186/s12935-020-01303-x Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Wang, Hui-shan
Zhang, Wen
Zhu, Han-long
Li, Quan-peng
Miao, Lin
Long noncoding RNA SNHG6 mainly functions as a competing endogenous RNA in human tumors
title Long noncoding RNA SNHG6 mainly functions as a competing endogenous RNA in human tumors
title_full Long noncoding RNA SNHG6 mainly functions as a competing endogenous RNA in human tumors
title_fullStr Long noncoding RNA SNHG6 mainly functions as a competing endogenous RNA in human tumors
title_full_unstemmed Long noncoding RNA SNHG6 mainly functions as a competing endogenous RNA in human tumors
title_short Long noncoding RNA SNHG6 mainly functions as a competing endogenous RNA in human tumors
title_sort long noncoding rna snhg6 mainly functions as a competing endogenous rna in human tumors
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275348/
https://www.ncbi.nlm.nih.gov/pubmed/32518528
http://dx.doi.org/10.1186/s12935-020-01303-x
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