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Overexpression of bHLH domain of HIF-1 failed to inhibit the HIF-1 transcriptional activity in hypoxia

BACKGROUND: Hypoxia inducible factor-1 (HIF-1) is considered as the most activated transcriptional factor in response to low oxygen level or hypoxia. HIF-1 binds the hypoxia response element (HRE) sequence in the promoter of different genes, mainly through the bHLH domain and activates the transcrip...

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Detalles Bibliográficos
Autores principales:	Sadeghi, Fatemeh, Kardar, Gholam Ali, Bolouri, Mohammad Reza, Nasri, Farzad, Sadri, Maryam, Falak, Reza
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275393/ https://www.ncbi.nlm.nih.gov/pubmed/32503642 http://dx.doi.org/10.1186/s40659-020-00293-4

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