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Progranulin inhibits LPS-induced macrophage M1 polarization via NF-кB and MAPK pathways

BACKGROUND: Macrophage M1 polarization plays a pivotal role in inflammatory diseases. Progranulin (PGRN) has potential anti-inflammation action, however, the effect of PGRN on macrophage M1 polarization has been poorly studied. Our study aimed to investigate the effect of PGRN on lipopolysaccharide...

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Detalles Bibliográficos
Autores principales:	Liu, Lianlian, Guo, Hongmei, Song, Aimei, Huang, Jiahui, Zhang, Yu, Jin, Shanshan, Li, Shutong, Zhang, Liguo, Yang, Chengzhe, Yang, Pishan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275413/ https://www.ncbi.nlm.nih.gov/pubmed/32503416 http://dx.doi.org/10.1186/s12865-020-00355-y

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