Th17 cells inhibit CD8(+) T cell migration by systematically downregulating CXCR3 expression via IL-17A/STAT3 in advanced-stage colorectal cancer patients

BACKGROUND: CD8(+) T cell trafficking to the tumor site is essential for effective colorectal cancer (CRC) immunotherapy. However, the mechanism underlying CD8(+) T cell infiltration in colorectal tumor tissues is not fully understood. In the present study, we investigated CD8(+) T cell infiltration...

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Detalles Bibliográficos
Autores principales: Wang, Dan, Yu, Weina, Lian, Jingyao, Wu, Qian, Liu, Shasha, Yang, Li, Li, Feng, Huang, Lan, Chen, Xinfeng, Zhang, Zhen, Li, Aitian, Liu, Jinbo, Sun, Zhenqiang, Wang, Junxia, Yuan, Weitang, Zhang, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275425/
https://www.ncbi.nlm.nih.gov/pubmed/32503584
http://dx.doi.org/10.1186/s13045-020-00897-z

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