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Relationships between abnormal neural activities and cognitive impairments in patients with drug-naive first-episode schizophrenia
BACKGROUND: Prior resting state functional Magnetic Resonance Imaging studies (rs-fMRI) via the regional homogeneity (ReHo) method have demonstrated inconsistent and conflicting results because of several confounding factors, such as small sample size, medicinal influence, and illness duration. Rela...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275517/ https://www.ncbi.nlm.nih.gov/pubmed/32503481 http://dx.doi.org/10.1186/s12888-020-02692-z |
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author | Yan, Wei Zhang, Rongrong Zhou, Min Lu, Shuiping Li, Wenmei Xie, Shiping Zhang, Ning |
author_facet | Yan, Wei Zhang, Rongrong Zhou, Min Lu, Shuiping Li, Wenmei Xie, Shiping Zhang, Ning |
author_sort | Yan, Wei |
collection | PubMed |
description | BACKGROUND: Prior resting state functional Magnetic Resonance Imaging studies (rs-fMRI) via the regional homogeneity (ReHo) method have demonstrated inconsistent and conflicting results because of several confounding factors, such as small sample size, medicinal influence, and illness duration. Relationships between ReHo measures and cognitive impairments in patients with drug-naive First-Episode Schizophrenia (dn-FES) are rarely reported. This study was conducted to explore the correlations between ReHo measures and cognitive deficits and clinical symptoms in patients with dn-FES. METHODS: A total of 69 patients with dn-FES and 74 healthy controls were recruited. MATRICS Consensus Cognitive Battery (MCCB), Wechsler Adult Intelligence Scale (WAIS), and Positive And Negative Syndrome Scale (PANSS) were used to assess cognitive function, Intelligence Quotient (IQ), and clinical symptoms, respectively. The correlations between ReHo maps and cognitive deficits and the severity of symptoms were examined using strict correlation analysis. RESULTS: ReHo values in right Middle Frontal Gyrus (MFG) and Superior Frontal Gyrus (SFG) increased in dn-FES group, whereas ReHo values in right cuneus decreased. Correlation analysis showed that the ReHo values in right MFG positively correlated with attention/vigilance impairments, social cognition deficits, and the severity of clinical manifestations. CONCLUSIONS: These findings suggested that abnormal spontaneous activities in right MFG reflect illness severity and cognitive deficits, which also serve as a basis for establishing objective diagnostic markers and might be a clinical intervention target for treating patients with schizophrenia. |
format | Online Article Text |
id | pubmed-7275517 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-72755172020-06-08 Relationships between abnormal neural activities and cognitive impairments in patients with drug-naive first-episode schizophrenia Yan, Wei Zhang, Rongrong Zhou, Min Lu, Shuiping Li, Wenmei Xie, Shiping Zhang, Ning BMC Psychiatry Research Article BACKGROUND: Prior resting state functional Magnetic Resonance Imaging studies (rs-fMRI) via the regional homogeneity (ReHo) method have demonstrated inconsistent and conflicting results because of several confounding factors, such as small sample size, medicinal influence, and illness duration. Relationships between ReHo measures and cognitive impairments in patients with drug-naive First-Episode Schizophrenia (dn-FES) are rarely reported. This study was conducted to explore the correlations between ReHo measures and cognitive deficits and clinical symptoms in patients with dn-FES. METHODS: A total of 69 patients with dn-FES and 74 healthy controls were recruited. MATRICS Consensus Cognitive Battery (MCCB), Wechsler Adult Intelligence Scale (WAIS), and Positive And Negative Syndrome Scale (PANSS) were used to assess cognitive function, Intelligence Quotient (IQ), and clinical symptoms, respectively. The correlations between ReHo maps and cognitive deficits and the severity of symptoms were examined using strict correlation analysis. RESULTS: ReHo values in right Middle Frontal Gyrus (MFG) and Superior Frontal Gyrus (SFG) increased in dn-FES group, whereas ReHo values in right cuneus decreased. Correlation analysis showed that the ReHo values in right MFG positively correlated with attention/vigilance impairments, social cognition deficits, and the severity of clinical manifestations. CONCLUSIONS: These findings suggested that abnormal spontaneous activities in right MFG reflect illness severity and cognitive deficits, which also serve as a basis for establishing objective diagnostic markers and might be a clinical intervention target for treating patients with schizophrenia. BioMed Central 2020-06-05 /pmc/articles/PMC7275517/ /pubmed/32503481 http://dx.doi.org/10.1186/s12888-020-02692-z Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Article Yan, Wei Zhang, Rongrong Zhou, Min Lu, Shuiping Li, Wenmei Xie, Shiping Zhang, Ning Relationships between abnormal neural activities and cognitive impairments in patients with drug-naive first-episode schizophrenia |
title | Relationships between abnormal neural activities and cognitive impairments in patients with drug-naive first-episode schizophrenia |
title_full | Relationships between abnormal neural activities and cognitive impairments in patients with drug-naive first-episode schizophrenia |
title_fullStr | Relationships between abnormal neural activities and cognitive impairments in patients with drug-naive first-episode schizophrenia |
title_full_unstemmed | Relationships between abnormal neural activities and cognitive impairments in patients with drug-naive first-episode schizophrenia |
title_short | Relationships between abnormal neural activities and cognitive impairments in patients with drug-naive first-episode schizophrenia |
title_sort | relationships between abnormal neural activities and cognitive impairments in patients with drug-naive first-episode schizophrenia |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275517/ https://www.ncbi.nlm.nih.gov/pubmed/32503481 http://dx.doi.org/10.1186/s12888-020-02692-z |
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