Clozapine rechallenge and initiation despite neutropenia- a practical, step-by-step guide

Clozapine remains the only drug treatment likely to benefit patients with treatment resistant schizophrenia. Its use is complicated by an increased risk of neutropenia and so there are stringent monitoring requirements and restrictions in those with previous neutropenia from any cause or from clozap...

Descripción completa

Detalles Bibliográficos
Autores principales: Silva, Edward, Higgins, Melanie, Hammer, Barbara, Stephenson, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275543/
https://www.ncbi.nlm.nih.gov/pubmed/32503471
http://dx.doi.org/10.1186/s12888-020-02592-2
_version_ 1783542807182442496
author Silva, Edward
Higgins, Melanie
Hammer, Barbara
Stephenson, Paul
author_facet Silva, Edward
Higgins, Melanie
Hammer, Barbara
Stephenson, Paul
author_sort Silva, Edward
collection PubMed
description Clozapine remains the only drug treatment likely to benefit patients with treatment resistant schizophrenia. Its use is complicated by an increased risk of neutropenia and so there are stringent monitoring requirements and restrictions in those with previous neutropenia from any cause or from clozapine in particular. Despite these difficulties clozapine may yet be used following neutropenia, albeit with caution. Having had involvement with 14 cases of clozapine use in these circumstances we set out our approach to the assessment of risks and benefits, risk mitigation and monitoring with a practical guide.
format Online
Article
Text
id pubmed-7275543
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-72755432020-06-08 Clozapine rechallenge and initiation despite neutropenia- a practical, step-by-step guide Silva, Edward Higgins, Melanie Hammer, Barbara Stephenson, Paul BMC Psychiatry Review Clozapine remains the only drug treatment likely to benefit patients with treatment resistant schizophrenia. Its use is complicated by an increased risk of neutropenia and so there are stringent monitoring requirements and restrictions in those with previous neutropenia from any cause or from clozapine in particular. Despite these difficulties clozapine may yet be used following neutropenia, albeit with caution. Having had involvement with 14 cases of clozapine use in these circumstances we set out our approach to the assessment of risks and benefits, risk mitigation and monitoring with a practical guide. BioMed Central 2020-06-05 /pmc/articles/PMC7275543/ /pubmed/32503471 http://dx.doi.org/10.1186/s12888-020-02592-2 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Silva, Edward
Higgins, Melanie
Hammer, Barbara
Stephenson, Paul
Clozapine rechallenge and initiation despite neutropenia- a practical, step-by-step guide
title Clozapine rechallenge and initiation despite neutropenia- a practical, step-by-step guide
title_full Clozapine rechallenge and initiation despite neutropenia- a practical, step-by-step guide
title_fullStr Clozapine rechallenge and initiation despite neutropenia- a practical, step-by-step guide
title_full_unstemmed Clozapine rechallenge and initiation despite neutropenia- a practical, step-by-step guide
title_short Clozapine rechallenge and initiation despite neutropenia- a practical, step-by-step guide
title_sort clozapine rechallenge and initiation despite neutropenia- a practical, step-by-step guide
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275543/
https://www.ncbi.nlm.nih.gov/pubmed/32503471
http://dx.doi.org/10.1186/s12888-020-02592-2
work_keys_str_mv AT silvaedward clozapinerechallengeandinitiationdespiteneutropeniaapracticalstepbystepguide
AT higginsmelanie clozapinerechallengeandinitiationdespiteneutropeniaapracticalstepbystepguide
AT hammerbarbara clozapinerechallengeandinitiationdespiteneutropeniaapracticalstepbystepguide
AT stephensonpaul clozapinerechallengeandinitiationdespiteneutropeniaapracticalstepbystepguide

Ejemplares similares